Global interest in edible herbs for health care and health promotion has increased significantly in recent years. Ganoderma lucidum is a forest fungus with a woody texture that has been used since ancient times to enhance health and prevent and treat many diseases due to its wide range of secondary metabolites with abundant medicinal properties. So far, many cellular mechanisms have been proposed to explain how the active metabolites function and the health and hygienic properties of this valuable medicinal fungus, including anti-cancer, anti-viral, anti-bacterial, enhanced cellular immunity, antioxidant and many more. This article reviews the scientific findings of scientists on the antimicrobial properties of the medicinal fungus G. lucidum.