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مرکز اطلاعات علمی SID1
اسکوپوس
مرکز اطلاعات علمی SID
ریسرچگیت
strs
نویسندگان: 

THYGESAN L.G. | LOKKE M.M. | MICKLANDER E.

اطلاعات دوره: 
  • سال: 

    2003
  • دوره: 

    14
  • شماره: 

    -
  • صفحات: 

    50-57
تعامل: 
  • استنادات: 

    391
  • بازدید: 

    10612
  • دانلود: 

    16455
کلیدواژه: 
چکیده: 

آمار یکساله:  

بازدید 10612

دانلود 16455 استناد 391 مرجع 0
نویسندگان: 

GARSID P. | WYETH P.

نشریه: 

STUDIES IN CONSERVATION

اطلاعات دوره: 
  • سال: 

    2003
  • دوره: 

    48
  • شماره: 

    3
  • صفحات: 

    0-0
تعامل: 
  • استنادات: 

    401
  • بازدید: 

    12239
  • دانلود: 

    18089
کلیدواژه: 
چکیده: 

آمار یکساله:  

بازدید 12239

دانلود 18089 استناد 401 مرجع 0
نویسندگان: 

CARDENAS G. | MIRAND S.P.

اطلاعات دوره: 
  • سال: 

    2004
  • دوره: 

    49
  • شماره: 

    4
  • صفحات: 

    291-295
تعامل: 
  • استنادات: 

    377
  • بازدید: 

    22408
  • دانلود: 

    14482
کلیدواژه: 
چکیده: 

آمار یکساله:  

بازدید 22408

دانلود 14482 استناد 377 مرجع 0
گارگاه ها آموزشی
اطلاعات دوره: 
  • سال: 

    1399
  • دوره: 

    91
  • شماره: 

    1
  • صفحات: 

    192-197
تعامل: 
  • استنادات: 

    0
  • بازدید: 

    598
  • دانلود: 

    492
چکیده: 

واکنش پذیری زیاد ترکیب اورانیوم هگزافلوراید عامل تولید ناخالصی هیدروژن فلوراید در فرایند صنعت غنی سازی می باشد. حضور این گاز مزاحم سبب برهم خوردن معادلات غنی سازی اورانیم می گردد، به همین دلیل اندازه گیری گاز هیدروژن فلوراید در بافت اورانیم هگزا فلوراید به عنوان یکی از فاکتورهای مهم در صنعت غنی سازی، با استفاده از طیف سنجی مادون قرمز صورت گرفته است. با استفاده از سیستم ورودی طراحی شده و سل گازی انعکاسی 10 متری، امکان آنالیز هیدروژن فلوراید در شرایطی بهتر از روش استاندارد ASTM میسر شد. کاهش چشم گیر میزان مصرف اورانیم هگزافلوراید (به میزان 80 درصد)، حذف به کارگیری ازت مایع در آماده سازی نمونه، ساده سازی روش نمونه گیری، از نتایج بهینه سازی روش می باشد. از بین پنج استاندارد و مقررات بین المللی موجود، ملاحظات استاندارد ISO/IEC 17025 مد نظر قرار گرفته و پارامترهای صحه گذاری از قبیل خطی بودن، صحت، دقت، حد تشخیص، حد اندازه گیری کمی و عدم قطعیت نتایج نیز برای تأثیر اثر خطاهای موجود مورد بررسی قرار گرفت.

آمار یکساله:  

بازدید 598

دانلود 492 استناد 0 مرجع 0
اطلاعات دوره: 
  • سال: 

    2014
  • دوره: 

    12
  • شماره: 

    2
  • صفحات: 

    79-84
تعامل: 
  • استنادات: 

    0
  • بازدید: 

    40962
  • دانلود: 

    15363
چکیده: 

Miconazole is an imidazole antifungal agent, commonly applied topically to the skin or mucous membranes. The aim of this study was to examine the alternative method for gaining mechanism or the bimolecular changes caused by the possible teratogenic effects of Miconazole on mice fetus brain tissue using FTIR-Microspectroscopy. The mice were injected with Miconazole (60 mg/Kg) on gestation day 9. Fetuses were dissected on day 15 of gestation and morphological and histological studies on the fetus were carried out. Sections (10 mm) of control and Miconazole treated fetus brain tissue were used for FTIR measurement in the mid- infrared region. The results were shown by spectra 2nd derivative and also subtracting from control spectra. A lower intensity in the lipid (2800-3000 cm-1) and amid I (1600-1800 cm-1) regions of Miconazole treated mice fetus brain tissue was observed compared to the control mice fetus brain tissue. No major spectral shifting was observed at amide I band, amide II band and nucleic acid regions. As a conclusion, FTIR-Microspectroscopy can be a useful tool for teratogenic measurement with a unique ability to identify the modified bimolecular structures in mice fetus tissues.

آمار یکساله:  

بازدید 40962

دانلود 15363 استناد 0 مرجع 0
اطلاعات دوره: 
  • سال: 

    2014
  • دوره: 

    12
  • شماره: 

    2
  • صفحات: 

    61-68
تعامل: 
  • استنادات: 

    0
  • بازدید: 

    35649
  • دانلود: 

    18945
چکیده: 

Researchers have found a big interest in biological application of Fourier Transform Infrared (FTIR) spectroscopy. Evaluating many diseases, staging them and studying the chemical structures of different formed compounds in diseases are some of the research applications of FTIR. Cancer is also one of these diseases. Researchers are trying to set up FTIR methods to detect and diagnose cancer cells and follow up the treatment steps using FTIR. In this regard, cancer cells and tissues are under investigation. In order to study cancer cells in lab, it is important to find out the proper cell density on the disk, at the first step. In this regard, the effect of different densities and positioning of cancer cells on FTIR supporting disk are studied in the present project. At the first step calibration of the instrument is checked using bovine serum albumin (BSA). Cancer cells were collected from culture dishes and washed with normal saline, twice. Different concentrations of cells (10000-320000 cells/uL) were located on ZnSe disks and dried prior to spectroscopy. The samples were scanned in the mid-infrared range of 4000-400 cm-1, with the resolution of 2 cm-1. Each spectrum was collected by 100 sample scans. Microscopic images of the disk were also taken to find out the distribution of the cells on the disk. The results of this study showed that the right amount of cell number and positioning on the disk is a very important parameter in bio-spectroscopic quality for biological purposes.

آمار یکساله:  

بازدید 35649

دانلود 18945 استناد 0 مرجع 0
strs
اطلاعات دوره: 
  • سال: 

    2014
  • دوره: 

    13
  • شماره: 

    SUPPL
  • صفحات: 

    101-111
تعامل: 
  • استنادات: 

    0
  • بازدید: 

    46322
  • دانلود: 

    25881
چکیده: 

Metronidazole is used to treat trichomoniasis, bacterial vaginosis, and other diseases. There are controversy aspects about its teratogenicity. A teratogenic agent can alter morphology or subsequent function of the fetus. The aim of this study was to examine an alternative method for the recognition of the mechanism or the bimolecular potential changes in mice fetus caused by Metronidazole using FTIR micro spectroscopy. The mice were injected with metronidazole (60 mg/Kg) on gestation day 9. Fetuses were dissected on day 15 of gestation and morphological and histological studies on the fetus were carried out. Serial sectioning (10 mm) of normal and metronidazole-treated brains and livers were used for FTIR measurement in the wave number region of 600- 3600 cm-1.The results showed that there were some variations between the fetus of normal and treated brain and liver. The band intensities in fetus brain and liver of test animals were reduced and shifted at 707 cm-1, 1155 cm-1, 1054 cm-1, 1256 cm-1 and 1219 cm-1, 1453 cm-1and 1525 cm-1, 1622 cm-1, 1645 cm-1 and 2944 cm-1, while the band intensities were increased and shifted at 879 cm-1, 810 cm-1, 1223 cm-1, 1256 cm-1 1360 cm-1, 1723 cm-1. It was concluded that most of variations in brain and liver of Metronidazole treated fetuses are in amid bands, nucleic acid and carbohydrate related bands. Based on these findings FTIR spectroscopy can be a useful tool for bio diagnostic.

آمار یکساله:  

بازدید 46322

دانلود 25881 استناد 0 مرجع 0
نویسندگان: 

CHEN J. | WU L. | PAN T.

اطلاعات دوره: 
  • سال: 

    2010
  • دوره: 

    -
  • شماره: 

    -
  • صفحات: 

    0-0
تعامل: 
  • استنادات: 

    383
  • بازدید: 

    11066
  • دانلود: 

    15214
کلیدواژه: 
چکیده: 

آمار یکساله:  

بازدید 11066

دانلود 15214 استناد 383 مرجع 0
اطلاعات دوره: 
  • سال: 

    2017
  • دوره: 

    0
  • شماره: 

    1
تعامل: 
  • بازدید: 

    92
  • دانلود: 

    41
چکیده: 

FTIR SPECTROSCOPY IS A TECHNIQUE TO IDENTIFY STRUCTURAL CHANGES OF MACROMOLECULES SUCH AS CARBOHYDRATES, PROTEIN, DNA AND LIPIDS.STUDY WAS UNDERTAKEN TOEVALUATE THE EFFECTS OF PURSLANE ON COPPER SULPHATE POISONING ON LIVER STRUCTURE CHANGES.THUS, TWENTY EIGHT WISTAR RATS WERE RANDOMLY ALLOCATED TO FOUR TREATMENT GROUPS. GROUP I) CONTROL, GROUP II) COPPER SULPHATE (200MG/KG BODYWEIGHT WAS APPLIED BYGAVAGE DAILY FOR FOUR WEEK, GROUP III) PURSLANE (GAVAGE400 MG/KG BODYWEIGHT DAILY FOR FOUR WEEKS) AND GROUP IV) COMBINED TREATMENT OF COPPER SULPHATEAND PURSLANE AS DESCRIBED IN GROUP II AND III. AT THE END OF THE STUDY, ANIMALS WERE SACRIFICED AND THE LIVER WAS REMOVED FOR FOURIER TRANSFORM INFRARED SPECTROSCOPY (FTIR).WE CONFIRMEDTHAT PURSLANE ADMINISTRATION PROTECTED THE CARBOHYDRATE STRUCTURAL DAMAGE THAT OCCURRED IN LIVER OF COPPER TREATED RATS.

آمار یکساله:  

بازدید 92

دانلود 41
اطلاعات دوره: 
  • سال: 

    2015
  • دوره: 

    14
  • شماره: 

    SUPPL
  • صفحات: 

    121-130
تعامل: 
  • استنادات: 

    0
  • بازدید: 

    38222
  • دانلود: 

    39043
چکیده: 

Phenobarbital is a phenobarbiturate used as a sedative, anticonvulsant or hypnotic with the doses prescribed and can cause teratogenic effects. The goal of this study was to examine an alternative method for the recognition of the mechanism or the bimolecular potential changes in mice fetus caused by Phenobarbital using FTIR micro spectroscopy. The mice were injected with Phenobarbital (120 mg/Kg) on gestation day 9. Fetuses were dissected on day 15 of gestation and morphological and histological studies on the fetus were carried out. Sections (10 μ m) of normal and Phenobarbital treated fetus brains and livers were used for FTIR measurement in the wave number region of 400-4000 cm. The results were shown by 2 derivatization of spectra and also subtracting from control spectra. In liver, the intensity at 1054 cm, 1155 cm, 1353 cm, 1453cm, 1645 cm, 1622 cm, 2944 cm, 2913 cm and 2845 cm were shifted and increased. In the brain, the intensity at 879 cm, 911 cm, 955 cm, 1223 cm, 1256 cm, 1304 cm, 1360 cm, 1453 cm, 1529 cm, 1636 cm, 2845 cm, 2915 cm and 2950 cm were increased and shifted. The most important changes of the fetus brain tissue are on the β structure of proteins due to the amide I bands at 1636 cm, while extensive effects on the DNA structure were obvious for the Phenobarbital treated liver tissues. As a conclusion, FTIR spectroscopy might well be assumed as a potentially powerful teratogenic measurement instrument with a unique ability to identify the modified bimolecular structures.

آمار یکساله:  

بازدید 38222

دانلود 39043 استناد 0 مرجع 0
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