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مرکز اطلاعات علمی SID1
اسکوپوس
مرکز اطلاعات علمی SID
ریسرچگیت
strs
Author(s): 

MARDER M. | PALADINI A.C.

Issue Info: 
  • Year: 

    2002
  • Volume: 

    2
  • Issue: 

    -
  • Pages: 

    853-867
Measures: 
  • Citations: 

    398
  • Views: 

    7249
  • Downloads: 

    17659
Keywords: 
Abstract: 

Yearly Impact:

View 7249

Download 17659 Citation 398 Refrence 0
Author(s): 

SINGH R.P. | AGRAWAL R.

Issue Info: 
  • Year: 

    2002
  • Volume: 

    4
  • Issue: 

    4
  • Pages: 

    655-663
Measures: 
  • Citations: 

    402
  • Views: 

    13844
  • Downloads: 

    18353
Keywords: 
Abstract: 

Yearly Impact:

View 13844

Download 18353 Citation 402 Refrence 0
Issue Info: 
  • Year: 

    2009
  • Volume: 

    8
  • Issue: 

    SUPPLEMENT 5
  • Pages: 

    52-56
Measures: 
  • Citations: 

    1206
  • Views: 

    56661
  • Downloads: 

    36161
Abstract: 

Background: Achillea talagonica (Asteraceae) is an endemic herbaceous plant in Iran with small yellow flowers and several times pinnately divided leaves in worm shape. The plant was found to be cytotoxic in our previous studies.Materials and Methods: A. talagonica was collected in May 2005 from Talegan in north of Iran during the full flowering stage. Dried aerial parts of the plant were reduced in to small pieces and percolated with ethyl acetate for 72 hours. The extract obtained was filtered and then concentrated under reduced pressure and completely dried by a freeze dryer. Column chromatography of the extract on silica gel and sephadex LH-20 yielded in isolation of three main components. Cytotoxic activity was evaluated against the Artemia salina larvae by the Brine Shrimp Cytotoxicity Bioassay.Results: Isolated compounds were identified as b-sitosterol (1), salvigenin (5- hydroxy 4', 6, 7- three methoxy flavone) (2) and santoflavon (5- hydroxy 4', 3', 6, 7- tetra methoxy flavone) (3). NMR data of all the isolated compounds showed good agreement with literature data.Conclusions: In our previous studies ethyl acetate extract of A. talagonica showed cytotoxic activity in brine shrimp lethality assay. The results of BST assay indicated that only santoflavone (3) showed a good cytotoxic activity (LC50=15 mg/ml) against A. salina larvae so this compound seems to be responsible for the extract toxicity of A. talagonica against Artemia nauplii.

Yearly Impact:

View 56661

Download 36161 Citation 1206 Refrence 1206
گارگاه ها آموزشی
Author(s): 

Issue Info: 
  • Year: 

    2017
  • Volume: 

    96
  • Issue: 

    -
  • Pages: 

    305-312
Measures: 
  • Citations: 

    395
  • Views: 

    12980
  • Downloads: 

    17057
Keywords: 
Abstract: 

Yearly Impact:

View 12980

Download 17057 Citation 395 Refrence 0
Author(s): 

SMITH M.T. | SKIBOLA C.F.

Issue Info: 
  • Year: 

    2000
  • Volume: 

    29
  • Issue: 

    3-4
  • Pages: 

    375-383
Measures: 
  • Citations: 

    1608
  • Views: 

    44913
  • Downloads: 

    18353
Keywords: 
Abstract: 

Yearly Impact:

View 44913

Download 18353 Citation 1608 Refrence 0
Issue Info: 
  • Year: 

    2012
  • Volume: 

    11
  • Issue: 

    3
  • Pages: 

    839-844
Measures: 
  • Citations: 

    0
  • Views: 

    54604
  • Downloads: 

    26807
Abstract: 

Five FLAVONOID glycosides were isolated from then -butanol soluble fraction of the ethanolic extract of Rapistrum rugosum and their structures were assigned from 1H- and 13C-NMR spectra (DEPT) with 2D NMR as quercetin-3- O-a-L-rhamnopyranoside (1), quercetin-3- O-b-D-xyloside (2), quercetin, 3-O-a- L-arabinopyranoside, 7- O-a-L-rhamnopyranoside (3), kaempferol 3- O-a-L-arabinopyranoside, 7- O-a-L-rhamnopyranoside (4) and rutin (5). The SRB cytotoxic assay was used to investigate the antitumor activities of n -butanol extract, compound 3 and its hexaacetate 3a, for the first time. Compounds 3 and 3a showed cytotoxic activity against the human cancer cell line, namely, HepG2 (hepatocellular carcinoma cell line) with IC50 (concentration of compound required to reduce cell survival by 50%) 0.86 mg/mL and 3.50 mg/mL, respectively. These results proved that compound 3, the major FLAVONOID of the n -butanol soluble fraction, has significant cytotoxic activity compared with the standard antitumor drug doxorubicin (0.60 mg/mL).

Yearly Impact:

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strs
Author(s): 

Journal: 

J Dunia Gizi

Issue Info: 
  • Year: 

    2021
  • Volume: 

    4
  • Issue: 

    -
  • Pages: 

    8-14
Measures: 
  • Citations: 

    1
  • Views: 

    0
  • Downloads: 

    59
Keywords: 
Abstract: 

Yearly Impact:

View 0

Download 59 Citation 1 Refrence 0
Author(s): 

HEIM K. | TAGLIAFERRO A. | BOBILYA D.

Issue Info: 
  • Year: 

    2002
  • Volume: 

    13
  • Issue: 

    10
  • Pages: 

    572-584
Measures: 
  • Citations: 

    372
  • Views: 

    14846
  • Downloads: 

    13879
Keywords: 
Abstract: 

Yearly Impact:

View 14846

Download 13879 Citation 372 Refrence 0
Author(s): 

Issue Info: 
  • Year: 

    2018
  • Volume: 

    128
  • Issue: 

    1
  • Pages: 

    0-0
Measures: 
  • Citations: 

    381
  • Views: 

    766
  • Downloads: 

    14909
Keywords: 
Abstract: 

Yearly Impact:

View 766

Download 14909 Citation 381 Refrence 0
Author(s): 

Journal: 

MOLECULES

Issue Info: 
  • Year: 

    2020
  • Volume: 

    25
  • Issue: 

    11
  • Pages: 

    0-0
Measures: 
  • Citations: 

    82
  • Views: 

    784
  • Downloads: 

    8292
Keywords: 
Abstract: 

Yearly Impact:

View 784

Download 8292 Citation 82 Refrence 0
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