Background and aims: The conflict between values transforms a situation or problem into an Ethical challenge. Due to high workload, nurses are frequently confronted with the Ethical challenges and despite having different specialities, they are incapable of confronting Ethical challenges. The aim of this study was to investigate Ethical challenges in nursing profession. Methods: This is a review article that was done in 2016, data were collected by searching through online databases such as Scopus, web of science, PubMed, Iran medex, iranpsycho Magiran and SID with the keywords challenge, ethics, nursing with no time limit. 27 articles were included in the present study. Results: The results of the study were categorized into three categories: Ethics fundamental (autonomy, avoidance of Damage, Usefulness, equality), moral decision making (moral uncertainty, Moral distress, Ethical tension), and Ethical challenges (professional, communication and educational challenges). Conclusion: Sensitivity to Ethical issues and challenges in the professional practice of nursing practice is vital and must be entered in training, clinincal and nursing research.