Background: Celiac disease (CD) is an autoimmune mediated gluten sensitive enteropathy and cardiac involvement in CD children is frequent. Objectives: This study aimed to investigate cardiac involvements in patients with celiac disease by using Doppler Tissue Echocardiography and conventional Echocardiography to identify myocardial dysfunctions in celiac patients compared to healthy individuals. Patients and Methods: This case-control and approved study was performed on 120 children with celiac disease and 60 healthy children aged 1-18 years old in a single center. Patients with valvular disease, rhythm abnormality, CHD, malignancy, systemic inflammatory diseases, diabetes mellitus, renal insufficiency, chronic obstructive pulmonary disease and hypertension were excluded from the study. The participants underwent Echocardiography. Data were analyzed through SPSS 17 using Student’ s t-test and Mann-Whitney U. A P value of < 0. 05 was considered as significant. Results: Out of 120 patients with celiac, 55. 83% were females and for the control group it was 43. 33%. The participants in the case and control groups were matched for sex and age. Weight and height showed significant differences between the groups. Right ejection time had significant mean differences of 245. 30 ± 24. 60 and 253 ± 22. 66 for the case and control groups respectively with the t =-2. 03 and P = 0. 044. Similar trends were observed for the left myocardial performance index by DTE with a mean of 0. 79 ± 0. 12 and 0. 72 ± 0. 12 for the case and control groups, respectively (t-3. 32, P = 0. 001). QT and heart rate by ECG and ET, IRT and MPI by DTE had significant differences in the case and control groups. LA in diastole and LVM and Peak A velocity had significant differences in both groups. ET, ICT, and IRT revealed significant differences in the case and control groups. Conclusions: Consistent with many study’ s results, we reached the conclusion that Doppler Tissue Echocardiography and Conventional Echocardiography are good determination methods of systolic and diastolic myocardial functions in patients with celiac disease. Between these two methods, the present study confirmed the importance and strong power for Doppler Tissue Echocardiography.