Purpose: To focus on clinical manifestations and epidemiology of thyroid EYE disease (TED) in Central Iran’, s population. Methods: In this retrospective case study, we analyzed all patients with TED who were referred to our oculoplastic clinic from 2015 to 2019. The patients’,epidemiological characteristics and clinical presentation were compared between different thyroid disease groups and genders. Results: Overall, 383 patients (155 male,40. 5% and 228 female,59. 5%) were included. The mean age was 39. 55 years (standard deviation ±,13. 45, range 10–, 72). Most patients (89%) were hyperthyroid with the highest duration of ocular involvement among all categories (25. 6 months). The most common signs on ophthalmic examinations were proptosis (80. 4%), followed by EYElid retraction (72. 3. 0%). TED was classified as mild in 24. 5%, moderate to severe in 67. 6%, and sight‑, threatening in 7. 9%. Thirty patients (7. 8%) had active TED. Conclusions: This series with a relatively more significant number of TED cases in Central Iran found similar epidemiological and clinical characteristics of TED compared to other studies from Iran. Most of our patients were hyperthyroid, with more females compared to males. Proptosis and EYElid retraction were the most common manifestations. Most TED patients were classified as moderate to severe.