Angiofibrom is the most common benign tumor of nasopharynx. Because of site of its origin (Superior border of sphenopalatine foramen), this tumor can extend to nasal cavity, paranasal sinuses, ptrygomaxillary fossa, infratemporal and temporal fossa and Intracranium. The most common symptoms are epistaxis and nasal obstruction. Diagnosis is based on Physical findings and radiology, biopsy may cause fatal bleeding and is avoidedIn a 14 Year old male with a large angiofibroma of nasopharynx, that had extended to nasal cavity (bilaterally), right maxillary sinuse, right ptrygomaxillary and infratemoral fossa, sphenoid sinuse and intracranium (Through parasellar), we prefered to use LefortI osteotomy for removal of the tumor, Because This approach provide an excellent direct access to above regions without facial scarring. This approach for surgery of angiofibroma was Performed for first time in Medical University of Esfahan.