ESOPHAGEAL CANCER is the second most common malignancy in Iranian men; it is the third in women. It is killing about 5800 Iranians each year. Squamous cell carcinoma (SCC) is presently the most common type of ESOPHAGEAL CANCER accounting for about 90% of all ESOPHAGEAL CANCERs in Iran. Recent studies in Iran have shown that there is a gradual increase in the incidence of adenocarcinoma of the distal esophagus along with gastric cardia adenocarcinoma. Thirty-five years ago, the age-adjusted incidence rate (ASR) of SCC of esophagus in Gonbad city, Golestan province, Northeast of Iran (>100 per 105 people per year), was found to be one of the highest rates for any single CANCER ever reported in the world. Recent studies have shown that the incidence of SCC in Gonbad has declined to less than half of what it was in the past. This decline in the incidence of ESOPHAGEAL SCC is in parallel with improvement in socioeconomic status of people living in this region. According to the recent CANCER registry data in Iran, there is still an obvious intra-country variability between the incidence of ESOPHAGEAL CANCER in South with an ASR of 3 for men and 2 for women in Kerman and 43 and 36, respectively, in northeastern province of Golestan. The reasons for this very high rate of SCC in northeastern Iran have been the subject of several studies during the last 35 years. According to the results of these studies, the suspected risk factors include low intake of fruits and vegetables, drinking hot tea, consumption of opium products and tobacco, H.pylori infection in stomach, using unhealthy drinking water from cistern and genetic susceptibility. The main suspected mutagens are polycyclic aromatic hydrocarbons (PAH) and N-Nitroso compounds. In order to embark on a primary and secondary prevention of this fatal CANCER further prospective studies are presently going on in the northeastern Iran. Golestan cohort study of ESOPHAGEAL CANCER with enrollment of 50,000 subjects is now in its follow-up phase. We expect simple and feasible evidence based preventive strategies to be implemented in future from the results of these studies.

ESOPHAGEAL CANCER is the second and third most common malignancy in Iranian males and females, respectively, claiming lives of approximately 5800 Iranians each year. Squamous cell carcinoma (SCC) is presently the most common type accounting for about 90% of all ESOPHAGEAL CANCERs in Iran. Recent studies have shown that there is a gradual increase in the incidence of adenocarcinoma of the distal esophagus along with gastric cardia adenocarcinoma.Thirty-five years ago, the age standardizied rate (ASR) of ESOPHAGEAL SCC in the city of Gonbad (Golestan Province, northeast of Iran) was found to be one of the highest rates for any single CANCER that had been reported worldwide (ASR >100/105/year). Recent studies have shown that the incidence of SCC in Gonbad has declined to less than half of what it was in the past. This decline in the incidence of ESOPHAGEAL SCC parallels an improvement in the socioeconomic situation of people living in this region. According to recent CANCER registry data in Iran there is still an obvious intracountry variability between the incidence of ESOPHAGEAL CANCER in the south with an ASR of 3 for males and 2 for females in Kerman and 43 and 36 in the northeastern province of Golestan. The reasons for this very high rate of SCC in northeastern Iran have been the subject of several studies during the past 35 years. According to results of these studies the suspected risk factors are: low intake of fruits and vegetables, drinking hot tea, consumption of opium products and tobacco, H.pylori infection in the stomach, using unhealthy drinking water from cisterns and genetic susceptibility. The main suspected mutagens are polycyclic aromatic hydrocarbons (PAH) and N-nitroso compounds. In order to embark primary and secondary prevention of this fatal CANCER, further prospective studies are presently underway in the region. The Golestan ESOPHAGEAL CANCER cohort study which follows of 50,000 subjects is on going. We expect simple and feasible evidence based preventive strategies to be implemented in the future according to the results of this study.

Metastasis of CANCERs to finger is a very rare finding. Herein, we report on an 80-year-old woman presented with a large painless ulceroproliferative lesion of her right thumb. The lesion was surgically excised. Pathological report revealed a papillary adenocarcinoma-a distant metastasis from the esophagus. The patient had an uneventful course and was discharged from the hospital

Background: ESOPHAGEAL CANCER is the 7th most common CANCER in Iran. The northern part of the country shows the highest incidence for this malignancy. In this study we present some epidemiological and clinicopathological characteristics of patients with ESOPHAGEAL carcinoma in this region.Methods: In a cross sectional study, 238 ESOPHAGEAL CANCER patients were enrolled in a prospective study of neoadjuvant chemo-radiation treatment in a 4-year period (2006-2009). In an oncology clinic their epidemiologic characteristics and clinicopathological findings were registered in a preplanned file. Data consisted of age, sex, race, occupation, residential location, smoking, addiction history, signs and symptoms, blood biochemistry profile, imaging and endoscopic findings. The data were analyzed with the SPSS software. Results: The mean age of the patients was (55% female) 59 years. They were mostly Fars (63%) and Turkmen (13%). Seventy two percent were residents of rural area, 20% were smokers and 22.3% were opium addict and its analogues. Only 1.3% of patients consumed alcohol. The most common presenting symptom was dysphagia (93.7%), mainly grade III dysphagia (53%). Location of tumor in esophagus was in the middle third in 53.4% and lower segment in 44.5%. 65 % of the patients had an abnormal esophagogram. On endoscopic evaluation the most common types of tumors were polypoid, vegetative and fungoid, respectively. Mean tumor length was 5.7 cm. The most common histology type was squamus cell carcinoma (99.1%) which was moderately differentiated in 51.3% of these patients. No significant relationship was found between the grade of dysphagia with the macroscopic type and the pathologic grade of the tumor in this study. Conclusion: Squamous cell carcinoma comprised more than 99% of all ESOPHAGEAL CANCERs in our patients and this histological type is the prominent type in the Northeast of Iran. Middle ESOPHAGEAL segment is the major site for this type of CANCER which unfortunately most patients present with grade III. Dysphasia reflects the advanced stage of the disease.

Background and aim: Non-melanoma skin CANCERs (NMSC) are one of the most prevalent malignancies of the human. Although the morality rate is not high for these CANCERs, they may cause high morbility for the patients. In addition to the skin type, factors such as sun exposure, head and neck radiotherapy, inappropriate use of sunscreen and cultural changes may increase the incidence of these CANCERs. The objective of this study was to determine NMSC in Isfahan.Materials and Methods: We used data of the CANCER resistery center for performing this study and the incidence of NMSC per 100,000 populations was determined. Results: Overall 1681 cases were registered. The incidence of NMSC was calculated to be 10.67/100,000population. The most common site for BCC and SCC was middle face. Conclusion: NMSC incidence in Isfahan is lower than west countries although this incidence is 10.67/100,000in a year. It means that 5-6 thousand cases of NMSC occur in Iran each year. We can prevent its morbidity and mortality by early correct diagnosis.

Background: Association between primary gastric CANCER and ESOPHAGEAL CANCER was reported by Michio Maeta, et al in 1982. They treated 114 Japanese patients with primary ESOPHAGEAL CANCER and found that 4.4% of them (5 patient 3) h!d simultaneous gastric CANCER. In another Japanese study which was done by Hoichikato, et al in Tokyo 44 case (3.9%) of a total 1,137 patients with ESOPHAGEAL CANCER had associated primary gastric CANCER. In this study we want to present association of ESOPHAGEAL CANCER and simultaneous primary gastric CANCER in a 52 y/o Iranian male.Case report: A 52 y/o Non-smoker male was admitted with dysphagia after eating solid foods, anorexia and weight loss since 2 months PTA. He also had history of 6omi4ing and nausea after eating each meal. Upper GI endoscopy revealed a ESOPHAGEAL infiltrative tumoral lesion in the 30 Cm from the incisura and an ulcerative infiltrative lesion in gastric antrum.Pathological findings included: well differentiated squamous cell carcinoma (SCC) of esophagus and poorly differentiated carcinoma of stomach. Metastasis work up revealed a large hetrogenous 4x7 cm mass in upper pole of rigt-sided adrenal and further endocrinologic assessment for excluding primary tumor of adrenal before biopsy of this mass was performed and results are pending.Result: In this case an association between primary gastric and ESOPHAGEAL CANCER was seen in an Iranian man.Coclusion: We suggest careful evaluation for gastric CANCER before surgery for ESOPHAGEAL CANCER.