In the present paper, we report two rare cases of Down Syndrome (DS); mosaic Down-Turner Syndrome and DS with rob (13; 14). Patient 1 karyotype is mos 45, X[41] / 47, XX, +21[59] and patient 2 karyotype is 46, XY, rob (13; 14)(q10; q10), +21. With these two unusual cases, we aimed to look at the most common numerical and structural chromosome anomalies from a different window and evaluate the phenotypic effect in the presence of different chromosomal anomalies. Our main goal is to evaluate the phenotypic characteristics of these two rare variants in the light of literature.

Objectives: Stigma is a negative value. Many behaviors are to ward Stigmatized people. Down Syndrome is one of conditions with Stigma. The aim of this study is to determine the sources of labeling in iranian Down Syndrome.Method: The View of 105 Down Syndrome families concerning stigma were conducted. All of Down Syndrome was under 50 years.Results: A fair proportion of Down Syndrome families perceived that stigma had a negative effect from social. Causes of stigma are different. Stigma due social interaction, Media and health professionals are significant than others.Conclusion: The diagnostic label of Down Syndrome may render the person and his family vulnerable to stigmatization. The most causes of stigma were determined; therefore, in the destigmatization programs, they must be attended. Stigma must be detected, too.