Purpose: To evaluate the effect of corneal flap hinge position on DRY EYE after Laser in Situ Keratomileusis (LASIK). Setting: Aban EYE Clinic, Isfahan, Iran.Methods: In a prospective double masked randomized controlled clinical trial, 212 consecutive EYEs of 106 myopic patients underwent LASIK; in each patient one EYE was randomly assigned for superior hinge and the other EYE for nasal hinge. Patients were examined preoperatively, 1 week, 1 month, 3 months and 6 months after surgery for: visual acuity, fluorescein tear film break up time, and Schirmer's baseline tear secretion test; Subjective evaluation of DRY EYE symptoms accomplished through Ocular Surface Disease Index (OSDI®) questionnaire at 1 month, 3 month, and 6 month postoperative visits.Results: Tear-film break up time was not significantly different with nasal or superior hinge flap techniques at pre-op, 1 week, 1 month, 3 month and 6 month post operative visits. No significant difference between two groups was found for amount of Schirmer's baseline tear secretion test at pre and post-op visits (P>0.05 for all comparisons between two groups, β: 0.2). Subjective evaluation of symptoms also showed no significant difference in 1 month, 3 month and 6 month postoperative visits. Conclusion: Our results show that nasal and superior hinge flap making methods do not affect signs and symptoms of DRY EYE after LASIK. We recommend that selecting hinge position should be done with the surgeons' preference and ease.