L-2-Hydroxyglutaric aciduria is a rare autosomal recessive inherited neurometabolic disorder.It is characterized by slow progressive neurological dysfunction with cerebellar ataxia, pyramidal and extrapyramidal signs, intellectual decline, and seizures. Herein, we report a case of a 7-year-old boy from Tehran whose symptoms and signs indicated leukoencephalopathy with macrocephaly and motor delay.

Background: Caffeine is isolated Methyl-xanthine, Alkaloid stimulants and it is the most commonly used drug in the world. The present study was to investigate the effect of caffeine on VO2max and Electrocardiograph in active male of student college after Bruce exhaustive exercise. Methods: 9 male active aged 25 (mean 20. 9± 1. 37 years, fat percent 11. 21± 3. 79 percentage and BMI 23. 49± 1. 69 kg/m2) allocated into two equal conditions: the supplement (5 mg. kg-1 caffeine) and without caffeine consumtion. After 60 min supplementation, subjects were participated in a single session of exhaustive Bruce Test. Changes in the VO2max and QT interval distance were meatured. Results: The results showed that caffeine had significant effect on the increased levels of VO2max after Bruce exhaustive exercise compared to the control condition. Also, levels of QT interval increased significantly after the exercise (p<0. 05). Conclusion: Caffeine could significantly increase the VO2max and increase QT after Bruce exhaustive test. Maybe, level and severity of exercise increase the ventricular depolarization and repolarization and cardiac performance.

Background: Hyperlactatemia is a well known index for tissue hypoperfusion which is not routinely measured in all surgical procedures. The aim of this study was to evaluate the DIAGNOSTIC value of base deficit in detecting hyperlactatemia and also predicting its postoperative complications in cardiac surgery. Methods: In a prospective observational study, 487 patients who underwent elective coronary artery bypass grafting or valve replacement surgery were evaluated. The serum lactate level and arterial blood gas (ABG) tests were measured simultaneously 3-5 times during operation and every six hours until 24h after operation. Hemodynamic changes during the operation, and also postoperative major complications consisting cardiac, pulmonary, neurologic, renal, infectious complications and death were recorded. Criterion for hyperlactatemia was considerate serum lactate³ 23 mg/dl and for metabolic acidosis, base deficit>5 mmol/L.Results: Intraoperative frequency of "at least one episode of' base deficit>5 mmol/L was 41.3% and also hyperlactatemia was 56.3%. There were sensitivity (48%), specificity (68%) and PPV (66%) of base deficit>5 mmol/L in diagnosis of hyperlactatemia, considering pre-test probability (56.3%) of hyperlactatemia and calculating LR=1.49 for "base deficit>5 mmol/L", the post-test probability of hyperlactatemia was estimated 70%. Considering frequency (pre-test probability) of 26.5% for postoperative complications and calculating LR=1.40 for both base deficit>5 mmol/L and hyperlactatemia, the post-test probability of postoperative complications was estimated 40% (in both tests). Conclusions: Because of importance of major postoperative complications, 40% probability of these events by observing base deficit>5 mmol/L or lactate ³3mg/dl can be sufficiently alert the anesthesiologist to do proper interventions.

In finance field, two ways are the most important to analysis, fundamental and technical analysis. Different experience showed that, using one of them, independently, cannot bring in return more than they are used together. So, it seems are needed more researches in this section of finance field. In technical analysis by using information such as prices and traded volume, INDICATORs are calculated and base on roles that introduce with them, decision are made. It probably the normal roles of INDICATORs are not profitable more than before and are not able to bring extreme return to investors that use them. In stock market without enough efficiency, using technical analysis caused returns more than using fundamental analysis, independently. In this paper will tested to optimize INDICATORs’ normal roles and is tried to produce efficient tools to bring return more. So that are used 50 companies that are much traded in years between 21 of march 2008 to 20 of march 2012 and optimizing are done first by using trying all of area and in second step by using enetic algorithm and finally compare to result from normal roles of INDICATORs and buy and hold.

Background: Metabolic syndrome (MetS), a cluster of cardiometabolic risk factors, consider as a manifestation of obesity. However, a proportion of obese patients do not develop MetS. The aim of our study was to deter-mine whether concentration of plasma adiponectin and leptin differ between metabolic unhealthy obese (MUO) patients and comparable age-and sex-matched control groups. Methods: In this case-control study, we assigned 51 obese patients with MetS (MUO) in cases group and 102 metabolic healthy obese (MHO) and normal weight metabolic healthy subjects matched for age and gender to cases in control groups. The study was conducted between December 2014 and February 2016 in the Endocri-nology Research Center of Tehran University of Medical Sciences, Tehran, Iran. We measured serum adi-ponectin, leptin, their ratio, and body composition in all subjects. Results: No significant differences were observed between MHO and MUO in term of total fat mass and trunk fat (P>0. 05). Compared to MHO and normal weight metabolic healthy subjects, MUO subjects had low-er levels of plasma adiponectin (P<0. 001) and lower plasma adiponectin to leptin ratio (P<0. 001) and a higher level of plasma leptin (P<0. 002). A Receiver Operator Characteristic curve was used to identify the ability of adiponectin and leptin level to predict the MetS. The area under the Receiver Operator Characteristic curve was 0. 66 (P<0. 01), 0. 73 (P<0. 001) and 0. 75 (P<0. 001) for leptin, adiponectin, and adiponectin/leptin ratio levels respectively. Conclusion: Our study introduced adiponectin and leptin as INDICATOR of MetS and obesity respectively.

INDICATOR of National Anticorruption Strategy of I.R.IRANCombating corruption need a multi pronged strategy because of the unintegrated and distributed nature of corruption. in this paper we review literature of anti corruption strategy and extract 26 INDICATOR with a preventive approach and present the INDICATOR in a economical , political , social , administrative section for national strategy of Islamic republic of Iran. the experts accept the INDICATOR and rank them. After survey the administrative INDICATOR take top rank by experts because of privilege of corruption in administrative system of Iran and selection of expert in a middle range of administrative system.