The major cause of increased bone resorption is hyperparathyroidism in children with renal failure.Radiolocigally it manifest as renal osteodystrophy with subperiostal resorption along the phalanges, involving also the distal phalangeal tufts. Hyperphosphatasia is a rare autosomal recessive disease and also is a condition with increased bone turnover. It appears to be due to deficiency of osteoprotegen. Radiological signs are expanded and bowed diaphyses. There is marked demineralization with a heterogeneous pattern. Osteopetrosis is an example of decreased bone resorption with calcified cartilage. The several types of the disease are all caused by an abnormality of osteoclastic resorption usually due to heritable mutation. Depending on its type the radiological manifestation is different. Increased bone density, metaphyseal undermodeling and signs of fluctuating activity of sclerosering process and others are found. D.Iatrogenic and toxic metabolic bone disorders. There are several iatrogenic and toxic disorders affecting the resorption of bone and calcified cartilage, including biphosphanate and prostaglandine or toxic effect by hypervitaminosis A and D and by heavy metal poisoning (lead). Also primary oxalosis should be classified in this category. Radiological changes in all these groups are different and characteristic. Increased bone density and opaque dense lines due to cyclic therapy will be found following biphosphanate treatment. Prostaglandins stimulate bone resorption with radiographic recognizable new bone formation. In chronic hypervitamin A hyperosteosis of the long bone and periosteal bone formation is the radiological finding. Hypervitaminosis D however shows an increase in width of provisional zone initially and cortical thickening later on. Lead lines due to excessive calcified cartilage are to be observed by lead poisoning. In oxalosis crystal deposit occurs in bone with formation of giant cell granulomatosis. Inflammatory response, osteosclerosis with greater cystic lesion will be developed. Based on above mentioned data the clinical and radiological findings of different metabolic diseases will be shown with special attention on characteristics of the radiological findings and their clinical signs and symptoms.