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مرکز اطلاعات علمی SID1
اسکوپوس
دانشگاه غیر انتفاعی مهر اروند
ریسرچگیت
strs
نویسندگان: 

اطلاعات دوره: 
  • سال: 

    2019
  • دوره: 

    20
  • شماره: 

    4
  • صفحات: 

    161-163
تعامل: 
  • استنادات: 

    441
  • بازدید: 

    9820
  • دانلود: 

    25269
کلیدواژه: 
چکیده: 

آمار یکساله:  

بازدید 9820

دانلود 25269 استناد 441 مرجع 0
اطلاعات دوره: 
  • سال: 

    2016
  • دوره: 

    6
  • شماره: 

    4
  • صفحات: 

    209-215
تعامل: 
  • استنادات: 

    0
  • بازدید: 

    64032
  • دانلود: 

    28498
چکیده: 

Background: Candidemia is the main cause of fungal nosocomial bloodstream infections and is related to meaningful mortality specially, in pediatrics. Mortality rate range from 5% to 71%, and it can reach as high as 81%. Delays in beginning of treatment have also been linked to intensified mortality. The epidemiology of Candida infection is changing from region to region. Regional surveillance of the epidemiology of Candidemia is necessary to identify patients at highest risk. The aim of this study is rapid and precise detection of Candida species isolated from blood stream by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique. Materials and Methods: This cross sectional study was conducted during October 2013 to January 2015. Sixteen Candida strains were isolated from 36 patients with positive blood culture in Milad hospital, Resalat Lab., Tehran, Iran. All isolates were identified by PCR-RFLP patterns after digestion with the restriction enzyme HpaII. Results: Candida albicans (72. 2%) and Candida glabrata (22. 2%) were the most prevalent species among isolates. Male to female ratio was 9/7, ranging in age from 4-16 years. Conclusion: Candida albicans remains the most frequently isolated species in the present study; however nonalbicans Candida species are increasing. Precise identification of Candida spp. can lead to a better management of Candidemia.

آمار یکساله:  

بازدید 64032

دانلود 28498 استناد 0 مرجع 0
اطلاعات دوره: 
  • سال: 

    2018
  • دوره: 

    6
  • شماره: 

    1
  • صفحات: 

    0-0
تعامل: 
  • استنادات: 

    0
  • بازدید: 

    49373
  • دانلود: 

    33519
چکیده: 

Introduction: Febrile neutropenic patients are at risk of serious infections. The aim of the present study is to identify the frequency, species, and susceptibility patterns of Candidemia in febrile neutropenic patients. Methods: This cross-sectional study was conducted on febrile neutropenic patients suspected with Candidemia who had been referred to 3 educational hospitals during 9 months. Results: The blood samples of 80 febrile neutropenic patients with the mean age of 48§ 16. 6 years were studied (60% female). Five (6. 25%) episodes of Candidemia were identified. The underlying disease was acute myeloid leukemia in 4 (80%) cases and all 5(100%) cases had central venous catheter and were receiving prophylactic ciprofloxacin and acyclovir. 100% of isolates were found to be susceptible to Voriconazole, 80% to Caspofungin, 60% to Amphotericin B, and 40% to Fluconazole. Conclusion: The frequency of Candidemia among the studied febrile neutropenia patients was 6. 25%, with 80% mortality rate, and themost frequently identified yeastwas Candida albicans (100%susceptible to Voriconazole).

آمار یکساله:  

بازدید 49373

دانلود 33519 استناد 0 مرجع 0
گارگاه ها آموزشی
اطلاعات دوره: 
  • سال: 

    2020
  • دوره: 

    8
  • شماره: 

    4
  • صفحات: 

    0-0
تعامل: 
  • استنادات: 

    0
  • بازدید: 

    9824
  • دانلود: 

    17596
چکیده: 

Objectives: The present study was conducted to raise attention to the frequency of Candida spp. and evaluation of risk factors of Candidemia in hospitalized neonates and children. Methods: Identifi cation of Candida at species level was done using the PCR-RFLP method. The Candida albicans complex and Candida parapsilosis complex were diff erentiated using the HWP1 gene amplifi cation and PCR-RFLP with NlaIII restriction enzyme, respectively. Results: Out of 75 blood culture specimens, 42 (84%) cases were positive for Candida spp. of whom 30 (71. 42%) and 12 (28. 57%) cases were female and male, respectively. Thirty-two (76%) Candidemia were presented in pediatrics with 6 years up to 12 years, 10 (23. 80%) in neonates of one month or less. In the present study, Candida parapsilosis (n =25; 59. 52%) was the most prevalent isolated species followed by C. albicans (n =11; 26. 19%), C. tropicalis (n =4; 9. 52%), and Candida glabrata (n =2; 4. 76%). Conclusions: According to potentially dangerous complications of bloodstream infection by Candida spp. in neonates and children, it is necessary to identify and eliminate the underlying conditions and risk factors of this disease.

آمار یکساله:  

بازدید 9824

دانلود 17596 استناد 0 مرجع 0
نویسندگان: 

اطلاعات دوره: 
  • سال: 

    2018
  • دوره: 

    36
  • شماره: 

    4
  • صفحات: 

    253-255
تعامل: 
  • استنادات: 

    455
  • بازدید: 

    6050
  • دانلود: 

    28126
کلیدواژه: 
چکیده: 

آمار یکساله:  

بازدید 6050

دانلود 28126 استناد 455 مرجع 0
اطلاعات دوره: 
  • سال: 

    2018
  • دوره: 

    6
  • شماره: 

    2
  • صفحات: 

    0-0
تعامل: 
  • استنادات: 

    0
  • بازدید: 

    42493
  • دانلود: 

    55913
چکیده: 

Background: The aspects of the epidemiology of bloodstream Candida infections including clinical features, the causal agents, underlying conditions, and risk factors have not been well-defined in Iranian pediatric patients. The aim of this observational study was to identify uncommon Candida species isolated from blood and other normally sterile specimens of the neonates and children admitted to intensive care units at Children’ s medical center, Tehran, Iran. Methods: The studywascarried out prospectivelyonpatients< 16 years, whowere hospitalized in Children’ s medical center, Tehran, Iran, during 25 months, from June 2014 to July 2016. Blood and other normally sterile specimens were collected from 6, 075 pediatric patients and only pure growth of yeasts were included the study. The yeast isolates were subjected to DNA extraction, PCR of ITSregion, and sequencing followed by Blast analysis to accurately identify the species. Results: A total of 16 out of 136 isolates were recognized as uncommon or rare Candida species. According to the sequence analysis, these isolates were identified as C. orthopsilosis (N = 5, 3. 7%), C. glabrate (n = 4, 2. 5%), C. dubliniensis (n = 2, 1. 5%), C. lusitaniae (n = 2, 1. 5%), C. kefyr (n = 2, 1. 5%), and C. intermedia (n = 1, 0. 75%) Conclusions: Candida species, which were once considered harmless, havenowbeen recognized as causative agents of Candidemia. It is essential to consider, manage, and control the conditions that lead to the development of these unusual but severe cases of Candidemia.

آمار یکساله:  

بازدید 42493

دانلود 55913 استناد 0 مرجع 0
strs
نویسندگان: 

RAZZAGHI R. | MOMEN HERAVI M. | ERAMI M. | NAZERI MEHDI

نشریه: 

CURRENT MEDICAL MYCOLOGY

اطلاعات دوره: 
  • سال: 

    2016
  • دوره: 

    2
  • شماره: 

    3
  • صفحات: 

    20-26
تعامل: 
  • استنادات: 

    0
  • بازدید: 

    70324
  • دانلود: 

    26676
چکیده: 

Background and Purpose: Candida species are considered a common cause of fungal blood stream infections, which are associated with considerable mortality and morbidity rates, especially in the admitted and immunocompromised patients. Despite the increase in new and available antifungal agents, the emergence of resistant strains is growing. Regarding this, the aim of the present study was to assess the fungal epidemiology of Candidemia and the antifungal susceptibility patterns against five current antifungal agents among the patients with prolonged fever, who were admitted to Beheshti Educational Hospital, Kashan, Iran.Materials and Methods: This cross-sectional study was conducted on 253 hospitalized patients with prolonged fever despite receiving broad-spectrum antibiotic therapy. Blood samples were collected aseptically, and then cultured using an automated blood culture system and conventional broth culture bottle. Candida isolates were identified at species level using morphological and physiological properties and produced color on the CHROMagar Candida. Furthermore, the antifungal susceptibility testing was performed using (CLSI M27-A3 and CLSI M27-S4) broth microdilution methods.Results: The most positive cultures were detected by the automated blood culture system. C. albicans (%50) was the most prevalent species, followed by C. glabrata (%40), and C. parapsilosis, (%10) respectively. The mortality rate was high (%60) and most patients with Candidemia were admitted to the Intensive Care Unit and Neonatal Intensive Care Unit. All isolates were susceptible to amphotericin B, while the highest resistance belonged to caspofungin.Conclusion: In this study, high resistance was reported, especially for caspofungin, which can be regarded as the emergence of caspofungin-resistant strains. Regarding this, the establishment of a surveillance and prevention program for the reduction of the emergence of resistant species is necessary.

آمار یکساله:  

بازدید 70324

دانلود 26676 استناد 0 مرجع 0
نویسندگان: 

اطلاعات دوره: 
  • سال: 

    2017
  • دوره: 

    2017
  • شماره: 

    -
  • صفحات: 

    0-0
تعامل: 
  • استنادات: 

    458
  • بازدید: 

    10257
  • دانلود: 

    28684
کلیدواژه: 
چکیده: 

آمار یکساله:  

بازدید 10257

دانلود 28684 استناد 458 مرجع 0
اطلاعات دوره: 
  • سال: 

    2019
  • دوره: 

    10
  • شماره: 

    1
  • صفحات: 

    73-79
تعامل: 
  • استنادات: 

    0
  • بازدید: 

    54172
  • دانلود: 

    22844
چکیده: 

Background: Bloodstream infection with Candida, or Candidemia, is the most common Candida systemic infection. In this study, we investigated the characteristics of patients with Candidemia to provide appropriate perspectives on these patients and reduce the associated mortality and morbidity. Methods: In this cross-sectional study, all patients with at least one positive blood culture of Candida spp. were investigated from April 2015 to March 2016 in Imam Khomeini Hospital Complex, Tehran, Iran. Results: A total of 74 patients (44 men and 30 women), with the mean age of 53. 15± 17. 89 years, were enrolled in this study. Non-albicans Candida species was responsible for Candidemia in 67. 6% (50. 74). The mean therapy intervals were 7 and 5. 6± 1. 5 days in patients who died and were discharged, respectively. The differences in frequencies of urinary catheter and mechanical ventilation were statistically significant among patients who died and survived (P<0. 001). Among the discharged patients, antifungal therapy was administered to 30. 8% (12. 39). The mortality rate was 54. 3% (19. 35) in the medical ward, 5. 7% (2. 35) in the surgical ward, and 40% (14. 35) in the intensive care unit (P=0. 041). The treatment was significantly associated with lower mortality than those with no treatment (OR=0. 150 [0. 023-0. 996], P=0. 05). Conclusion: The number of Candidemia cases caused by non-albicans Candida species is continuously increasing in our center. We demonstrated the epidemiologic characteristics of patients with Candidemia and the significant effects of timely and appropriate treatment on their outcomes. Further studies are needed to illuminate more aspects of this healthcare problem.

آمار یکساله:  

بازدید 54172

دانلود 22844 استناد 0 مرجع 0
اطلاعات دوره: 
  • سال: 

    2022
  • دوره: 

    40
  • شماره: 

    668
  • صفحات: 

    248-255
تعامل: 
  • استنادات: 

    0
  • بازدید: 

    92
  • دانلود: 

    7848
چکیده: 

Background: Candidemia showed high morbidity and mortality and should be diagnosed immediately. The aim of this study was to provide a simple and rapid method for direct detection of Candida in the blood, using conjugated antibodies with gold nanoparticles by eht agglutination method. Methods: In this study, yeast species isolated from 40 blood samples of patients tested by the BACTEC method were used. After identifying the etiologic agents by morphological and molecular methods, a mixture of yeast antigens was prepared. Briefly, a mixture of antigens was prepared from the Candida isolates detected from Candidemia, and injected into healthy rabbit skin with complete adjuvant to produce antibodies. After injecting the incomplete adjuvant in four reminders, blood samples and serum were finally prepared from the rabbit. Antibody production and its efficacy were confirmed by ELISA method. Gold nanoparticles were chemically conjugated with antibodies. For rapid diagnosis of Candidemia, the nanoparticle method was examined on the blood of four patients and blood contaminated with a certain number of Candida yeasts in the laboratory. Findings: Candida albicans was the most common etiologic agent of Candidemia, followed by Candida glabrata and Candida parapsilosis complex. In determining the tue-foo nanoparticle method, the least yeast detectable in the patient's blood was one yeast. The sensitivity and specificity of the nanoparticle method for detecting Candida in the blood of four patients compared to blood culture was 100%. Conclusion: Under our laboratory conditions, if testing 15 µ, l blood of a suspected patient to Candidemia containing one yeast or even just Candida antigens tesfpte to 35 microliters of the ltlfstreptntp conjugated antibodies, it shows agglutination during one minute.

آمار یکساله:  

بازدید 92

دانلود 7848 استناد 0 مرجع 0
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