Context: Several studies have controversial results regarding the association between Borna disease virus (BDV) and CHRONIC FATIGUE SYNDROME (CFS). The present systematic review and meta-analysis investigated the association between CFS and BDV. Evidence Acquisition: The present study was conducted based on the PRISMA guidelines for systematic review and meta-analysis studies. To avoid bias, all procedures of the study were performed by two researchers independently. A comprehensive search was performed using online databases, including PubMed, Scopus, Embase, PsycINFO, science Direct, Cochrane Library, web of science, and Google scholar using the MeSH keywords until December 12th, 2016. Heterogeneity among studies was evaluated using Cochran’ s Q test I2 Index. Finally, the random effect model was used for combined Odds Ratio (OR) using Review Manger software version 5. 3. 5. Results: Among 9 eligible studies comprising 610 cases and 2176 controls, the total OR for association between BDV and CFS was estimated to be 10. 41 (95% confidence interval [CI]: 4. 24-25. 55, P < 0. 0001). For subgroup analysis by the diagnostic methods (ELISA, RT-PCR, and Western blot), OR was 2. 47 (95% CI: 0. 77-7. 96, P=0. 13), 12. 20 (95% CI: 1. 66-89. 57, P=0. 01), and 28. 36 (95% CI: 3. 76-213. 85, P=0. 001), respectively (test for subgroup differences: P=0. 08; I2=59. 5). Subgroup analysis for BDV and CFS association by antigens and antibodies had an OR of 12. 20 (1. 66, 89. 57) and 8. 20 (3. 32, 20. 22), respectively (test for subgroup differences: P=0. 72; I2=0). Conclusions: This study supports the association between BDV and CFS and shows the role of viral agents in etiology of CFS. Therefore, viral agents may play a role in the etiology of neuropsychiatric disorders.

Background: CHRONIC FATIGUE SYNDROME (CFS) is a complex condition involving severe FATIGUE and disabling musculoskeletal and cognitive symptoms. We reported that 6, 12 and 24 months following infectious mononucleosis (IM), 13%, 7% and 4% of adolescents, respectively, met criteria for CFS. Whether endocrinologic or immunologic dysfunction accompanies CFS is unclear.Objectives: To determine if salivary cortisol levels or NK cell percentage and function 6, 12 and 24 months following IM in adolescents who met criteria for CFS and recovered, matched controls differ.Patients and Methods: Nine adolescents with CFS and nine matched, recovered controls had morning and nighttime salivary cortisol as well as NK cell number and function measured blindly 6, 12 and 24 months following IM.Results: Three subjects with CFS had a depressed morning salivary cortisol; one control subject had a single depressed nighttime cortisol. There was no difference in NK cell percentage or decreased function between cases and recovered controls. Conclusions: We found little evidence of depressed salivary cortisol levels and no decreased NK cell function in adolescents with CFS following IM.

Background: Migraine is one of the most common causes of headache characterize by pulsatile headache. Most patients with migraine experience CHRONIC FATIGUE SYNDROME. This SYNDROME includes CHRONIC FATIGUE for at least 6 months with neurological symptoms and muscular pain. One of the first line agents in migraine treatment is sodium valproate. In addition, usage of fluoxetine as a prophylactic treatment of migraine has been effective in recent researches. In this research, a comparison between sodium valproate and fluoxetine in treatment of patients with migraine and CHRONIC FATIGUE SYNDROME was done.Methods: In this clinical trial study, 64 patients with migraine and CHRONIC FATIGUE SYNDROME were enrolled.They were divided into two equal groups of 32 participants. Each group took one of the fluoxetine (20 mg daily) or sodium valproate (400 mg daily) for 8 weeks. The groups were compared in aspect of intensity score and frequency of headaches. Student's t and ANOVA statistical tests were used to analysis the results.Findings: The mean headache intensity score decreased in both sodium valproate and fluoxetine groups by 34.83% and 22.82%, respectively. In addition, the mean headache frequency decreased in both fluoxetine and sodium valproate groups by 23.68% and 40.54%, respectively.Conclusion: It could be understood that both sodium valproate and fluoxetine are effective in treatment of migraine with history of CHRONIC FATIGUE SYNDROME, yet sodium valproate was more effective. The effectiveness of fluoxetine was obvious in patients with depression history.

Overtraining SYNDROME is a common cause of underperformance of athletes.CHRONIC FATIGUE, muscle ache, lost of coordination, weight loss, mood changes and immune suppression are the concomitant symptoms. Definite laboratory findings are not determined yet. Clinical experts usually prescribe rest complete or partial for overt rained athletes, but training modification, nutritional and psychological intervention are the other actions. Overtraining SYNDROME could be detrimental for any athlete, because it needs a relatively long period of time for management.The assessment and treatment is a challenging process, and an over trained athlete maybe diagnosed too late. Accurate diagnosis needs differential diagnosis of the other related conditions.Scientific literature review shows good evidence-base research in this respect.However, debates remain about the underlying mechanisms. In the future, we need more in-depth studies in the fields of diagnosis, treatment and rehabilitation.

Background: There is a need to examine the prevalence of pediatric CHRONIC FATIGUE SYNDROME (CFS) and Myalgic Encephalomyelitis (ME) in the general community, as well as the relative frequency of CFS and ME among various groups (e.g., different age groups, genders, racial/ethnic groups, and socioeconomic strata) and to compare these individuals with community controls.Objectives: In the present study, we describe an ongoing NIH-funded study which will answer basic epidemiologic pediatric issues for pediatric CFS and ME.Materials and Methods: We used a multiple-stage design, beginning with a brief screening for CFS- and ME-like symptomatology, followed by a more rigorous medical and psychiatric diagnostic evaluation.Results: We provide two case studies showing the types of data we are collecting, and how the data are being used to inform diagnostic decisions.Conclusions: Our methods will allow us to determine the prevalence of pediatric CFS and ME status in the general community.

Introduction: Psycho-social factors have impact on quality of life in patients with CHRONIC FATIGUE and influencing the therapeutic outcomes in these patients. The aim of this research was to investigate predictive role of psychological and demographical factors on quality of life in patients with CHRONIC FATIGUE SYNDROME.Method: In cross-sectional design study, 393 outpatients (150 men and 243 women) with CHRONIC FATIGUE SYNDROME in attendants to hospital's clinics of Tehran University of Medical Sciences selected by convenience sampling. Data collected by Demographical Information Questionnaire, Chalder FATIGUE Scale and Clinical Interview Schedule (CIS-IV), Quality of Life Scale (WHO- QOL-BREF) and the Hospital Anxiety and Depression Scale (HADS) and analyzed by correlation and stepwise multiple regression.Results: There was a significantly negative relationship among depression, anxiety, age and quality of life (P<0.001). Depression, anxiety, and age significantly predicted variation of quality of life in patients with CHRONIC FATIGUE SYNDROME (P<0.001) and totally explain 61% of quality of life (R2=0.61). Depression weight in explain of quality of life was highest (0.556).Conclusion: Depression, anxiety and patient's age important for quality of life in patients with CHRONIC FATIGUE SYNDROME. Setting an agenda of planning for treatment of depression and anxiety in older aged patients with CHRONIC FATIGUE SYNDROME is necessity for basic quality of life promotion in these patients.

The purpose of the present study was to predict the CHRONIC FATIGUE SYNDROME in mothers of children with cancer based on their empathy and guilt. The research method was correlational. The statistical population included all mothers who had children diagnosed with cancer between summer and autumn of 2019 from among whom 87 mothers were studied using convenient sampling method with an internet survey. The tools of this study were Interpersonal Guilt Questionnaire (IGQ-67), Interpersonal Response Questionnaire (IRI) and Chalder CHRONIC FATIGUE Questionnaire (CFQ-11). The obtained data were analyzed using Pearson Correlation and Multiple Regression with SPSS21. The results of the data analysis showed that CHRONIC FATIGUE SYNDROME had a positive and significant relationship with general guilt and its dimensions; including survivor guilt, separation guilt, omnipotence guilt, and self-hate guilt, and with two dimensions of empathy; perspective and Imagination. Also, the dimensions of omnipotence guilt and fantasy predicted 60/8 percent of variance of CHRONIC FATIGUE SYNDROME. According to the role of guilt and empathy in CHRONIC FATIGUE experience of mothers of children with cancer psychological interventions related to emotion regulation and management can play an important role in reducing psychological burnout.