Background: CHRONIC FATIGUE SYNDROME is a common disease that is increasingly growing incidence in recent decades and for which there is no effective treatment. The aim of this study is to review the benefits of dietary interventions in reducing the symptoms of this SYNDROME.Methods: In order to search articles, the words CHRONIC FATIGUE SYNDROME, Fibromyalgia, Diet and Food in data bases include PubMed, Science direct, Scopus between the years 2009 and 2014 were used. The articles that were directly related to the topic of this review were selected.Results: Dietary interventions are often safer and less expensive in compared with standard drug therapy.Moreover, these interventions can also be controlled by patients themselves. The prevalence of food allergies and food intolerances in patients who suffer from CHRONIC FATIGUE SYNDROME are higher than the general population, therefore, most of the restrictions are applied on dairy products and cereals. Since there is not a homogeneous pattern of food avidness hence dietary restrictions should be based on food allergies and food intolerances.Significant reduction in pain and stiffness scores was to shown by using the phytonutrient rich Medical Food compared with the control groups having a vegetarian diet is effective for improving the symptoms of this SYNDROME.Some data suggested that nutritional deficiencies are involved in causing the disease Such as inadequate intakes of magnesium, selenium, zinc, iodine, iron, melatonin, vitamins and branched chains amino acids. Consequently, nutritional supplementation is necessary, although another study using a broad-spectrum nutritional supplement for the treatment of symptoms associated with the disease did not support the benefits of supplementation.Conclusion: further research are needed in order to find potential benefits for patients who suffer from CHRONIC FATIGUE SYNDROME. Due to the dominant situation of oxidative stress and lower antioxidant capacity in these patients having low levels of certain nutrients such as magnesium and selenium, it seems a series of interventions which will get dietary antioxidants increases are effective in reducing the symptoms of this SYNDROME.