Objective(s): Methicillin-resistant Staphylococcus aureus (MRSA) is one of the major health hazards AND became of greater public health concern since the emergence of community-ACQUIRED MRSA. This work aimed to study the prevalence of mecA, femA, femB, lukS-PV, lukF-PV (PVL), intI, AND intII genes among community-ACQUIRED (CA) hospital-ACQUIRED (HA) MRSA to increase vigilance in the diagnosis AND management of suspected infections. Materials AND Methods: S. aureus isolates recovered from clinical samples were classified into community or hospital-ACQUIRED AND tested for their antibiotic susceptibility against 19 antibiotics. All isolates were screened for mecA, femA, femB, lukS-PV, lukF-PV, intI, AND intII genes. Statistical correlations were carried out. Results: Out of 338 S. aureus isolates, only 105 were MRSA AND classified as 77 CA-MRSA AND 28 HAMRSA. mecA AND femA genes were present in all HA-MRSA AND CA-MRSA isolates. femB was found in all HA-MRSA AND 93. 5% of CA-MRSA isolates. PVL genes were detected in 28. 6% HA-MRSA isolates AND 92. 2% CA-MRSA. intI gene was recovered from 60. 7% HA-MRSA isolates AND 37. 7% CA-MRSA isolates while the intII gene recovered from only 10. 7% HA-MRSA isolates AND 6. 5% CA-MRSA. Conclusion: The high prevalence of MRSA colonizing the groin, axilla, AND nose may play a significant role in endogenous infection, re-infection, AND also acts as a route for MRSA transmission. mecA AND femA genes could be used as a sole AND fast step for identification of MRSA, while PVL genes cannot be used as a sole stable marker for CA-MRSA identification.