All along the history of medicine, CASE REPORTs have always been a rich resource for teaching and research. Nowadays CASE REPORTs are published in many medical journals. Publishing these REPORTs often sounds easy, but if not provided in a systematic approach, usually have little value for other researchers and the rejection rate can be extremely high. As the number of submitted REPORTs to medical journals are increasing, the author should know how he/she can select and REPORT the CASE in order to persuade editors to accept the REPORT. Recently, the CASE REPORTs have been considered as a source of reliable evidence in evidence based medicine. Interestingly, evidence based REPORTing of CASEs has come to the center of attention of modern article writers.The CASE must be chosen properly and presented in a brief but informative way. Both positive and negative outstanding results related to the CASE must be noted. Discussing characteristics and unique aspects of the CASE is of paramount importance. The author should try to cite some important references in the discussion section of the article. In the present review, We tried to describe the way in which a clinician can write and publish a classical CASE REPORT.