All along the history of medicine, CASE REPORTs have always been a rich resource for teaching and research. Nowadays CASE REPORTs are published in many medical journals. Publishing these REPORTs often sounds easy, but if not provided in a systematic approach, usually have little value for other researchers and the rejection rate can be extremely high. As the number of submitted REPORTs to medical journals are increasing, the author should know how he/she can select and REPORT the CASE in order to persuade editors to accept the REPORT. Recently, the CASE REPORTs have been considered as a source of reliable evidence in evidence based medicine. Interestingly, evidence based REPORTing of CASEs has come to the center of attention of modern article writers.The CASE must be chosen properly and presented in a brief but informative way. Both positive and negative outstanding results related to the CASE must be noted. Discussing characteristics and unique aspects of the CASE is of paramount importance. The author should try to cite some important references in the discussion section of the article. In the present review, We tried to describe the way in which a clinician  can write and publish a classical CASE REPORT.

About one century ago, Garrot defined the first disease of inbron error of metabolism. Many diseases have been classified in this category. Organic acidemia with multiple manifestation is one of them. A 12 year old boy with several episodes of metabolic acidosis and one attack with loss of conciousness, but with lack of skin manifestation was admitted to the clinic. His diagnosis as methyl malonic acidemia has definitly been confirmed by sending a sample aboard. Although such diagnosis is difficult to make in Iran, but our information about such CASE will be helpful in correct diagnosis of any CASEs with unexplained metabolic acidosis and developmental delay.

IUD T380A is one of the most effective, reversible, long term methods of contraception all over the world based on the experience of World Health Organization and our own observation of women who continued to use the IUD beyond 10 years or even longer years. In this article one CASE of Intrauterine device removal after 22 years is REPORTed without complications and pregnancy.

Intracerebral schwannoma has been known as a rare entity of intracranial tumors. It has been demonstrated that Schwann cells commonly arise from the peripheral nervous system, and do not exist in the parenchyma of the brain. The etiology and pathogenesis of these tumors in this uncommon location is unclear. However, several hypotheses have been concerned on the development and pathogenesis of these tumors. One of them supposed that schwannomas may originate from small vessels in the cortical and periventricular area, but Feigin and Ogata have suggested that mesenchymal multipotential cells may differentiate into Schwann cells. . . .

Lymphomatous involvement of the appendix is rare and most of them are found accidentally from appendectomies to treat appendicitis. Here we REPORT three CASEs of primary lymphoma of appendix of 10 year-old boy, 23-year-old man and 24-year-old woman that presented with abdominal pain to our hospital and the tumors were discovered during routine appendectomy for suspected "appendicitis". Our CASEs underwent chemotherapy regimen and they were asymptomatic respectively at 14, 17, and 18 months following-up. In the literature review of the tumors of the appendix, most of the begin tumors of appendix are treated with surgery alone. Lymphoma requires CHOP-like chemotherapy and carcinoid tumor treated according to the size of the tumor<2 with appendectomy alone and>2 with right hemicolectomy. The preferred treatment for adenocarcinoma of appendix is right hemicolectomy and the role of chemotherapy is unclear but when lymph node involvement is present, chemotherapy seems to be accepted.

While carcinoma of breast is common condition, stromal sarcomas are rare tumors of breast, amongst which fibrosarcoma accounts for 16% of CASEs. Only a few CASE REPORTs are available in the international literature. We REPORT a CASE of fibrosarcoma of breast, which presented as an unencapsulated mass in the right breast of a 60-year-old female. This CASE was diagnosed after exclusion of all possible differential diagnoses namely metaplastic carcinoma, cystosarcoma phylloides and other sarcomas of breast owing to its different histogenesis and prognostic behavior, in the light of detailed histopathological examination and immunohistochemical profile.

Introduction: Exfoliative Cheilitis (EC) is a rare chronic inflammatory condition affecting the vermillion border of the lips and characterized by excessive production of keratin. In this paper, a CASE of chronic EC that was relatively resistant to usual treatment is to be introduced. Also, we explain its clinical course and treatment procedures and measures.CASE Presentation: We REPORT a 25-year-old Iranian woman presented with desquamation of her lips. History, clinical feature and histopathological examination revealed a diagnosis of EC.Conclusions: Although treatment of EC in the present study had considerable success in the short-term follow-up, it should be noted, due to the unknown of the exact cause, no specific treatment or protocol has still been identified.

Cystic Hygroma is a well-recognized lesion in paediatric patients but it is very rare in adults. We REPORT here a CASE of Cervical Cystic Hygroma in a 45 yr old male. The reasons to present this CASE are 1) Its rarity in adults 2) Unusual age of presentation 3) Simulates various benign and malignant lesions at this site 4) Is a diagnostic challenge and 5) Role of histology for definitive postoperative diagnosis.