It has been established that a reduction in the serum lipids decreases the clinical effects and morbidity and mortality in patients suffering from coronary heart disease. Thus it was decided to conduct a study evaluating the effect of CARDIAC REHABILITATION on lipid profile in CARDIAC patients. In this clinical trial which was carried out on 120 patients who had reported to the CARDIAC REHABILITATION unit and were suffering from myocardial infarction, or else had undergone a coronary artery bypass surgery or an angioplasty.At first the 14 hour fasting blood samples of two groups were sent for serum total cholesterol (T.Cho), triglycerides (TG), LDL-cholesterol (LDL-C), HDL-cholesterol (HDL-C) and in the same manner 12 weeks later, the same samples were taken and measured. The following data was obtained using students test.Sixty patients participated in CARDIAC REHABILITATION program including 24 exercise sessions (45-60 minute/session), dietary consultation and mental health and 60 patients (control group) being the same as the intervention group in age, socioeconomic status, serum lipids profile, history of coronary heart disease and other risk factors who didnt participate in CARDIAC REHABILITATION program because of being far from this center or other reasons.T.Cho, TG and LDL-C of intervention group had decreased in 70%,62% and 76% of patients and in 86% patients, HDL-C showed an increase. T.Cho, TG, LDL-C and HDL-C was normalized in 35%, 30%, 68% and 66%, respectively after finishing their 2 month course which overall showed a 20, 56, and 30 mg/dl reduction in serum lipids respectively and 0.8 reduction in LDL-C/HDL-C (P<0.05) and 5 mg/dl increase serum HDL-C( P<0.05 ) in intervention group vs. control group.The decrease in T.Cho, TG and LDL-C and increase in HDL-C in all patients and normalization of lipid profile in most of them shows the importance of REHABILITATION in CARDIAC patients and the need for its continuity.