Background: Moderate intensity exercise enhances the endogenous enzymatic antioxidant defense system. The increase in antioxidant capacity in Heavy and prolonged high-intensity exercise is not sufficient and may result in the breaking capacity of detoxification reactions of compounds of oxygen to the body. It has been proven that after intense exercise Instead of increasing the antioxidant capacity the lipid peroxidation and muscle damage occurs. Consumption of Antioxidants enhances the antioxidant status and may reduce the damaging effects of radicals during intense exercise.The purpose of this study was to review the studies that examined the association between antioxidant intake and muscle damage.Methods: In the present study two completely separate searches in PubMed and Google Scholar, Scopus and SID using Antioxidants, muscle injury, exercise, vitamin C, ascorbic acid, vitamin E, extracts of articles with clinical trial similar articles were eliminated and a total of 8 papers were studied.Results: At present, evidence suggests that dietary supplements containing Antioxidants to prevent oxidative stress and muscle damage after exercise is very beneficial.Conclusions: Some of the studies from Improved indicators of muscle damage in athletes after taking Antioxidants have spoken; But there are studies that these effects have not been reported and this need for clinical trials and other studies will tell. It is also recommended that additional studies with larger sample size and with different doses and in different sports athletes will be scrutinized.