Background and Objectives: Obesity is a major health issue linked to conditions like diabetes, hypertension, and hyperlipidemia. Infectobesity suggests that certain microorganisms may contribute to obesity. Human Adenovirus serotypes, particularly Human Adenovirus type-36 (HAdV-36), Human Adenovirus type-5 (HAdV-5), and Human Adenovirus type-37 (HAdV-37), are thought to influence body fat regulation. This study investigates the relationship between Immunoglobulin G (IgG) positivity for HAdV-5 and HAdV-37 and obesity, aiming to provide data on the infectious etiology of obesity. Materials and Methods: Blood samples separated into serums from obese (BMI ≥30) and non-obese (BMI 18.5-25) individuals were tested for HAdV-5 and HAdV-37 seropositivity using ELISA kits and seropositivity rates between the groups were compared. Results: HAdV-37 antibody positivity was significantly higher in obese patients (39/48) compared to the control group (24/42) (p=0.011). For HAdV-5, antibody positivity was similar in both groups (26 individuals each) with no significant difference (p=0.461). No significant gender-related differences were found for either serotype. Conclusion: The study suggests HAdV-37 may be associated with obesity, while no such relationship was found for HAdV-5. There was no gender association for either serotype. These results align with existing literature on HAdV-37, but further research is needed to confirm the link between Adenoviruses and obesity and explore potential treatment options.

Allergy poses a heavy health burden in modern society. Other than symptom-relieving medications, the only available treatment approach is allergen-specific immunotherapy, which in spite of offering a potential cure, requires a long treatment duration with multiple doses of allergen administration and carries a risk of anaphylaxis. Gene therapy has shown advantages in experimental studies for treatment of tumors, genetic diseases, chronic infections, and allergy. To date, Adenovirus has been the most extensively used gene transfer vector, and offers high efficiency and safety. Here, we review studies of Adenovirus-mediated gene therapy targeting different steps in the development of allergic diseases. Adenovirus-mediated gene therapy might be a promising add-on therapy for allergy treatment.

In 1996, an outbreak of an acute highly contagious respiratory and ophthalmic disease occurred in a quail breeding farm, which produced a high mortality rate in quails. In order to determine the etiologic agent of the disease, samples were taken from conjunctiva, respiratory tract, and intestinal contents of affected birds which showed conjunctivitis and severe respiratory symptoms. By use of tests such as inoculation into 9-12 days old SPF chick embryos via the allantoic sac, cultivation on primary chick embryo liver cells, electron microscopic examination, H & E staining of the monolayers, thermal and lipid solvent stability, pH resistance, agglutination of rat RBCs and also serological tests (Le neutralization, cross neutralization, agar gel precipitation and electrophoresis) were carried out. The results showed that the causative agent is quail bronchitis virus (QBV). This disease has been reported by Razi vaccine and serum research institute in Iran for the first time.

Background: Respiratory virus infections represent a major public health problem because of their worldwide occurrence, ease of spread in the community and considerable morbidity and mortality. They are one of the most common reasons for hospitalization of children under the age of six. In some cases, infection with two different viruses increase the severity of disease which lead to the hospitalization.Case presentation: Among 202 samples related to children under the age of six with respiratory infections, two dual infections of Adenovirus with other respiratory viruses with PCR test were detected.Conclusion: Mixed respiratory viral infections are sometimes associated with severe disease and recognition of coinfection is important. Dual infections of Adenovirus with respiratory syncytial virus (RSV) and Swine origin influenza A (H1N1) virus were demonstrated. The evidence showed that the co-infection of Adenovirus with swine origin influenza A (H1N1), has increased the severity of disease which lead to the hospitalization.