Background and Aim: According to previous studies, surgical closure of atrial septal defects (ASDs) was considered as the standard treatment. Two surgical methods, the conventional sternotomy (CSA: median sternotomy) and ante lateral thoracotomy were used. This study was carried out to compare early results of the two techniques in ASD's closure.Materials and Methods: In this descriptive-analytical study from March 1998 to March 2004, the records of 73 patients with ASDs referring to Shahid Madany Hospital - affiliated to Tabriz University of Medical Sciences- were studied. The obtained data were analysed through filling out questionnaires; Fisher, and Mann-Whitney accurate tests were used for statistical analyses at the significant level of P £0.05.Results: Out of 73 patients, 38 cases had undergone thoracotomy (group I); and 35 of them had experienced sternotomy (group II). The difference between mean surgery time in group I (4.33 hours) and in group II (3.43 hours) was significant at P<0.001. Duration of hospitalization between the two groups (10.08 and 12.79 days, respectively)- P=0.01, was significant. There was no significant differences on mean cross-aortic clamping time (32.35 and 35.88 minutes, respectively - P=0.41), mean time of extracorporeal circulation (65.68 and 69.48 minutes, respectively, - P=0.27). Besides, there was no significant difference between the two groups regarding the amount of drainage.Conclusion: Right ANTEROLATERAL thoracotomy for ASD closure can be an appropriate technique, in terms of lower hospitalization days, limited surgical scar and better cosmetic outcome.