Search Result

4096

Results Found

Relevance

Filter

Newest

Filter

Most Viewed

Filter

Most Downloaded

Filter

Most Cited

Filter

Pages Count

410

Go To Page

Search Results/Filters    

Filters

Year

Banks



Expert Group









Full-Text


مرکز اطلاعات علمی SID1
اسکوپوس
مرکز اطلاعات علمی SID
ریسرچگیت
strs
Author(s): 

GATENBY R.A. | GILLIES R.J.

Issue Info: 
  • Year: 

    2004
  • Volume: 

    4
  • Issue: 

    -
  • Pages: 

    891-899
Measures: 
  • Citations: 

    409
  • Views: 

    17333
  • Downloads: 

    19588
Keywords: 
Abstract: 

Yearly Impact:

View 17333

Download 19588 Citation 409 Refrence 0
Author(s): 

Journal: 

SCIENCE-

Issue Info: 
  • Year: 

    2018
  • Volume: 

    360
  • Issue: 

    6387
  • Pages: 

    449-453
Measures: 
  • Citations: 

    398
  • Views: 

    5991
  • Downloads: 

    17659
Keywords: 
Abstract: 

Yearly Impact:

View 5991

Download 17659 Citation 398 Refrence 0
Journal: 

HEPATITIS MONTHLY

Issue Info: 
  • Year: 

    2021
  • Volume: 

    21
  • Issue: 

    5
  • Pages: 

    0-0
Measures: 
  • Citations: 

    0
  • Views: 

    19211
  • Downloads: 

    28910
Abstract: 

Background: Hepatic stellate cells (HSCs) are the key effector cells in the occurrence and development of liver fibrosis, while AEROBIC GLYCOLYSIS is one of the important metabolic characteristics of HSC activation. 6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase-3 (PFKFB3) is a homodimeric bifunctional enzyme, which is a rate-limiting enzyme in GLYCOLYSIS. This metabolite is important for the dynamic regulation of glycolytic flux. However, little is known about the role of PFKFB3 in liver fibrosis. Objectives: In this study, we aimed to explore the effects of PFKFB3 on AEROBIC GLYCOLYSIS in the process of HSC trans-differentiation and liver fibrosis. Methods: Immunohistochemical (IHC) staining and immunofluorescence assays were used to examine PFKFB3 expression in mice fibrotic liver tissue. The determination of extracellular acidification rate was used to examine changes in AEROBIC glycolytic flux, lactate production levels, and glucose consumption levels in HSCs upon TGF- 1 stimulation. Western blot analysis of the expression of PFKFB3, -SMA protein, and type I collagen was done. Liver histopathology was also examined. Besides, glycolytic inhibition by pharmacologic approaches was used to demonstrate the critical role of GLYCOLYSIS in liver fibrosis. Results: The PFKFB3 protein expression was increased in mouse fibrotic liver tissue. In addition, immunofluorescence revealed the colocalization of PFKFB3 and alpha-smooth muscle actin ( -SMA) protein. In vitro experiments showed that PFKFB3 could promote GLYCOLYSIS flux, lactic acid production, and glucose consumption of hepatic stellate cells. The PFKFB3 inhibitor was used in a mouse model of liver fibrosis, and the inhibition of PFKFB3 reduced the degree of liver inflammation and liver fibrosis. Conclusions: PFKFB3 can promote HSC AEROBIC GLYCOLYSIS, which, in turn, promotes HSC activation and liver fibrosis.

Yearly Impact:

View 19211

Download 28910 Citation 0 Refrence 0
گارگاه ها آموزشی
Author(s): 

Issue Info: 
  • Year: 

    2018
  • Volume: 

    3
  • Issue: 

    -
  • Pages: 

    1-4
Measures: 
  • Citations: 

    381
  • Views: 

    3541
  • Downloads: 

    14970
Keywords: 
Abstract: 

Yearly Impact:

View 3541

Download 14970 Citation 381 Refrence 0
Author(s): 

GRANCHI C. | MINUTOLO F.

Journal: 

CHEMMEDCHEM

Issue Info: 
  • Year: 

    2012
  • Volume: 

    7
  • Issue: 

    8
  • Pages: 

    1318-1350
Measures: 
  • Citations: 

    371
  • Views: 

    12123
  • Downloads: 

    13701
Keywords: 
Abstract: 

Yearly Impact:

View 12123

Download 13701 Citation 371 Refrence 0
Journal: 

OFOGH-E-DANESH

Issue Info: 
  • Year: 

    2005
  • Volume: 

    11
  • Issue: 

    1
  • Pages: 

    38-43
Measures: 
  • Citations: 

    0
  • Views: 

    1784
  • Downloads: 

    654
Abstract: 

Background and Aim: Thalassemia is the name of a group of genetic blood disorders. Thalassemia is an inherited disease of the red blood cells, classified as a hemoglobinopathy. In the research patients were selected major thalassemia for aldolase, hexokinase enzymes activity level, Serum Ferritin arterial blood oxygen were measured.Materials and Methods: In the experimental research, 50 patients were selected among 700 patients with major thalassemia who were treated in Sayedolshohada hospital in Isfahan. Serum Ferritin, arterial blood oxygen and Aldolase – Hexokinase enzymes activity level were measured in these patients.Results: A comparison was performed between mean level of serum ferritin, mean level of arterial blood oxygen, and activity level of Aldolase- Hexokinase enzymes.Conclusion: Mean level of Serum Ferrtin in 50 patients with major Thalasemia 237 µg/ml was made. According to the findings the increase of Aldolase- Hexokinase is increase with the increase of Serum Ferritin level.

Yearly Impact:

View 1784

Download 654 Citation 0 Refrence 0
strs
Author(s): 

Journal: 

EBIOMEDICINE

Issue Info: 
  • Year: 

    2019
  • Volume: 

    47
  • Issue: 

    -
  • Pages: 

    402-413
Measures: 
  • Citations: 

    410
  • Views: 

    7891
  • Downloads: 

    19766
Keywords: 
Abstract: 

Yearly Impact:

View 7891

Download 19766 Citation 410 Refrence 0
Issue Info: 
  • Year: 

    2010
  • Volume: 

    6
  • Issue: 

    2 (22)
  • Pages: 

    123-130
Measures: 
  • Citations: 

    1
  • Views: 

    572
  • Downloads: 

    206
Abstract: 

Introduction: Diabetes Type II is considered as the heterogeneous group of the metabolic diseases which contribute to inducing chronic hyper-glycemic and other disorders concerned with the metabolism of carbohydrates, fat and protein. This disease is a result of disorders in either or both of secretion insulin and insulin function. It is characterized by the long-term symptoms of vessels, nerves, kidneys and eyes. The present research intends to investigate the influence of the selected AEROBIC exercises for eight weeks on platelet, AEROBIC power, TC/LDL ratio, TC/HDL ratio and fibrinogen in middle-aged male individuals with Diabetes Type II from Tabas.Materials and Methods: This is an applied research study of the method of Semi Experimental. Twenty subjects were randomly selected out of a population of 1500 persons ranging in age from 40 to 55 years old. The subjects’ rate of blood sugar was ranging between 120 and 250 deciliter. They were of the average height of 170 (165-175) centimeters and the average weight of 80 (75-85) Kilograms. The subjects’ Body Mass Index was estimated less than 25. They were randomly divided into two groups: the control group and the experimental group. The selected AEROBIC activities included: the 12-minute Cooper Test using Third Mill and Work-Meter Bike.Before starting the exercises and after 12 hours of fasting, ten milliliters of blood was bled from the arm vein of the subjects of both groups.Similarly, the second phase of bleeding was done after eight weeks of exercising. Paired t-Test was used to analyze the data. A significance level of p<0.05 was set for this research and the normality of data was tested using Kolamograph method.Results : The selected AEROBIC exercises do not have any significant effect on the rate of platelet (P>0.409), fibrinogen (P>0.985) and TG/LDL (P>0.900) ratio in the patients with Diabetes Type II, but it has a significant effect on TG/HDL ratio (P<0.000 (and the AEROBIC power (P<0.000).Conclusion : Physical activities with an intensity of 60% to 80% HRR have the desirable effects on some blood factors in the patients with Diabetes Type II. Therefore, it is recommended that diabetes specialists prescribe exercises as a supplementary treatment along with medicinal treatment.

Yearly Impact:

View 572

Download 206 Citation 1 Refrence 0
Issue Info: 
  • Year: 

    2019
  • Volume: 

    18
  • Issue: 

    2
  • Pages: 

    153-162
Measures: 
  • Citations: 

    0
  • Views: 

    40883
  • Downloads: 

    45927
Abstract: 

Tumor cells rely on GLYCOLYSIS for their energy supply with the production of lactate even in normoxia condition, which is named AEROBIC GLYCOLYSIS or Warburg effect. Therefore, high glucose (HG) concentration provides a favorable condition for increasing proliferation, angiogenesis and decreasing apoptosis, but its molecular mechanisms are still unknown. The objective of this study is to investigate HG condition on tumor cells behavior including proliferation, apoptosis, and an angiogenesis mediator. In this study, MCF-7 derived from human breast adenocarcinoma, were cultured in DMEM with two different concentrations of glucose for 48 h (5. 5 mM as normal glucose (NG) condition and 25 mM as HG condition). We used Zingiber officinale extraction for the inhibition of NF-κ B. Cell proliferation assay was done by direct counting, cell viability by MTT method, bcl-2 by Immunocytochemistry, apoptosis by Hoechst/PI double staining and vascular endothelium growth factor (VEGF) by ELISA. Results showed that HG increased lactate production, significantly. HG increased cell proliferation, cell viability, VEGF secretion, and bcl-2 expression while it decreased apoptosis. However, when HG was combined with Zingiber officinale extraction, cell proliferation, cell viability, VEGF secretion and bcl-2 expression decreased and apoptosis increased significantly due to inhibition of NF-κ B. Results revealed that HG increased cell proliferation, angiogenesis and decreased apoptosis due to activation of NF-κ B pathway. Moreover, the probable mechanism of the activation of NF-κ B in HG is increasing reactive oxygen species (ROS) in this condition that can activate NF-κ B directly.

Yearly Impact:

View 40883

Download 45927 Citation 0 Refrence 0
Author(s): 

Issue Info: 
  • Year: 

    2019
  • Volume: 

    145
  • Issue: 

    4
  • Pages: 

    967-999
Measures: 
  • Citations: 

    388
  • Views: 

    2091
  • Downloads: 

    15944
Keywords: 
Abstract: 

Yearly Impact:

View 2091

Download 15944 Citation 388 Refrence 0
litScript