High-density polyethylene (HDPE) pipes find versatile applicability for transportation of water, sewage and slurry from one place to another. Hence, these pipes undergo tremendous pressure by the fluid carried. The present work entails the optimization of the withstanding pressure of the HDPE pipes using Taguchi technique. The traditional heuristic methodology stresses on a trial and error approach and relies heavily upon the accumulated experience of the (Process) engineers for determining the optimal (Process) control parameters. This results in setting up of less-than-optimal values. Hence, there arouse a necessity to determine optimal (Process) control parameters for the pipe extrusion (Process), which can ensure robust pipe quality and (Process) reliability. In the proposed optimization strategy, the design of experiments (DoE) are conducted wherein different control parameter combinations are analyzed by considering multiple setting levels of each control parameter. The concept of signal-to-noise ratio (S/N ratio) is applied and ultimately optimum values of (Process) control parameters are obtained as: pushing zone temperature of 166 oC, Dimmer speed at 08 rpm, and Die head temperature to be 192 oC. Confirmation experimental run is also conducted to verify the analysis and research result and values proved to be in synchronization with the main experimental findings and the withstanding pressure showed a significant improvement from 0.60 to 1.004 Mpa.