Isfahan province as a tourism hub and location at the crossroads of northern and southern corridor, the impact on the development and stability of the country. This study aims to evaluate the spatial dispersion of hotels in Isfahan province, its role in the development of domestic tourism in order to increase economic profit, social, cultural and environmental tourism, the tourism industry to the current planning and direction Future investments in established hotel with spatial planning approach formulated. The main purpose of this study was to survey the spatial dispersion of hotels in Isfahan Province and its role in the development of domestic tourism. The study, depending on the target application and the nature and methods of descriptive research, analytical and solidarity. The sample consisted of experts Administration of Cultural Heritage, Handicrafts and Tourism Isfahan province are university professors and consultants. In this study, experts in population due to the low volume of population, almost the entire population were selected and sampling have been carried out. The method of collecting data in this study, library research and field study (questionnaire). The analysis and rating of effective factors in the development of domestic tourism model was used TOPSISS. The results show that the spatial dispersion of effective development of domestic tourism hotels in Isfahan province. The results of this survey point out the significance of the relationship between spatial arrangement of hotels and their occupancy rate noted. The results could Administration of Cultural Heritage, Handicrafts and Tourism Isfahan province, the Housing and Urban Development, and the governments of the province and municipalities, investors, academic institutions and students and researchers interested in this field is used.