Background: Regarding the adverse effects of sexual dysfunction in mental health of the menopause woman and their families, detecting related factors of sexual dysfunction in this period seems to be essential. This study aimed to determine the associative factors of sexual dysfunction in menopause.Methods: This study was a cross sectional one. In this study simple random sampling was used to enroll 174 married women. Data were collected by questionnaires, through interviews and descriptive and inferential statistical methods, t-test, X2 and X2 mantel Hanszel test were used to analyze the data through SPSS software.Results: The relative frequency of sexual dysfunction in menopause is 72.4%, and the variables such as depression, spouse' relations quality and sexual knowledge were significantly associated with sexual dysfunctions. The findings also showed that no significant association exist between reproductive and personal characteristic such as spouses' age difference, marriage length, number of children and marriage status with sexual dysfunction in menopausal period.Conclusion: Sexual function can be affected by psychiatry disorders and lack of knowledge, regarding the creation of many psychological and community injuries following sexual dysfunction, therefore the role of health professionals in consulting and education is emphasized.