Background: There is no validated instrument for Persian-speaking students to apply the socialecological resilience theory (SERT), which emphasizes the ecological resources for developing resilience. The study aimed at developing the student social-ecological resilience measure (Student-SERM) in Iran’ s context. Methods: Three separate samples of undergraduates participated in this mixed-methods research from the University of Tehran, Iran. Phase-1 qualitatively explored the resilience features in the university setting, to devise the university-specific subscale (USS). Phase-2 piloted the construct validity and reliability of the Student-SERM in 242 undergraduates, who also completed Depression, Anxiety, and Stress Scale (DASS-21). Phase-3, as a cross-validation study, investigated 487 undergraduates, who completed the refined Student-SERM, Hospital Anxiety and Depression Scale (HADS), and three indices screening academic performance, loneliness, and suicide acceptability. Exploratory factor analysis (EFA) and confirmatory factor analysis (CFA), Pearson’ s correlation, and Cronbach’ s alpha were performed. Results: Phase-1 yielded nine items for USS. In phase-2, EFA indicated the construct validity of the main 20-item measure (RMSEA=0. 06 and SRMR=0. 04) and the nine-item USS (RMSEA = 0. 07 and SRMR = 0. 04), and the reliability and convergent/divergent validity were confirmed. In phase-3, EFA (RMSEA = 0. 07 and SRMR = 0. 04) and CFA (RMSEA = 0. 07, CFI = 0. 89, TLI = 0. 87, and SRMR = 0. 07) in two separate subsamples and CFA (RMSEA = 0. 06, CFI = 0. 92, TLI = 0. 90, and SRMR = 0. 06) in the total sample indicated the construct validity of the refined Student-SERM, including family, peer, culture, growth, and USS subscales. The reliability and convergent/ divergent validity were also reconfirmed. Conclusion: The Student-SERM incorporates ecological resources, accounting for the students’ resilience. Since the resilience process involves a return to healthy functioning after adversity, further research can examine the application of Student-SERM in high-risk student populations.