Introduction: heart failure (HF) related hospitalization constitutes a significant proportion of healthcare cost. Unchanging rates of readmission during recent years, shows the importance of addressing this problem. Methods: Patients admitted with heart failure diagnosis in our institution during April 2018 to August 2018 were selected. Clinical, para-clinical and imaging data were recorded. All included patients were followed up for 6 months. The primary endpoints of the study were prevalence of early readmission and the predictors of that. Secondary end points were inhospital and 6-month post-discharge mortality rate and late readmission rate. Results: After excluding 94 patients due to missing data, 428 patients were selected. Mean age of patients was 58. 5 years ( ±,17. 4) and 61% of patients were male. During follow-up, 99 patients (24%) were readmitted. Early re-admission (30-day) occurred in 27 of the patients (6. 6%). The predictors of readmission were older age (P = 0. 006), lower LVEF (P < 0. 0001), higher body weight (P = 0. 01), ICD/CRT implantation (P = 0. 001), Lower sodium (P = 0. 01), higher Pro-BNP (P = 0. 01), Higher WBC count (P = 0. 01) and higher BUN level (P = 0. 02). Independent predictors of early readmission were history of device implantation (P = 0. 007), lower LVEF (P = 0. 016), QRS duration more than 120 ms (P = 0. 037), higher levels of BUN (P = 0. 008), higher levels of Pro-BNP (P = 0. 037) and higher levels of uric acid (P = 0. 035). Secondary end points including in-hospital and 6-month post-discharge mortality occurred in 11% and 14. 4% of patients respectively. Conclusion: Lower age of our heart failure patients and high prevalence of ischemic cardiomyopathy, necessitate focusing on more preventable factors related to heart failure.