This paper is concerned with asphaltene deposition in fluid flowing through pipelines. Brownian diffusion and drag, gravitational, thermophoresis, buoyancy, and shear removal are considered as possible mechanisms in the asphaltene deposition process. The thermo-physical properties of the fluid were obtained from Iranian oil fields. A model was used in the pipeline deposition modeling to predict the asphaltene deposition rates under flow conditions. The effects of particle size, temperature gradient, and fluid velocity were studied on asphaltene deposition rate. The results showed that, among the above-mentioned mechanisms, the gravitational and thermophoresis forces played a significant role in the formation of the deposit under the flow conditions. To verify the model, some predictions were compared with the available aerosol deposition data in the literature.