Some HEAVY METALS are nutritionally essential elements playing key roles in different physiological and biological processes, like: iron, cobalt, zinc, copper, chromium, molybdenum, selenium and manganese, while some others are considered as the potentially toxic elements in high amounts or certain chemical forms. Nowadays, various usage of HEAVY METALS in industry, agriculture, medicine and technology has led to a widespread distribution in nature raising concerns about their effects on human health and environment. Metallic ions may interact with cellular components such as DNA and nuclear proteins leading to apoptosis and carcinogenesis arising from DNA damage and structural changes. As a result, exposure to HEAVY METALS through ingestion, inhalation and dermal contact causes several health problems such as, cardiovascular diseases, neurological and neurobehavioral abnormalities, diabetes, blood abnormalities and various types of cancer. Due to extensive damage caused by HEAVY metal poisoning on various organs of the body, the investigation and identification of therapeutic methods for poisoning with HEAVY METALS is very important. The most common method for the removal of HEAVY METALS from the body is administration of chemical chelators. Recently, medicinal herbs have attracted the attention of researchers as the potential treatments for the HEAVY METALS poisoning because of their fewer side effects. In the present study, we review the potential of medicinal herbs such as: Allium sativum (garlic), Silybum marianum (milk thistle), Coriandrum sativum (cilantro), Ginkgo biloba (gingko), Curcuma longa (turmeric), phytochelatins, triphala, herbal fibers and Chlorophyta (green algae) to treat HEAVY metal poisoning.

The production of agricultural waste has been increasing with the development of the agricultural economy in recent years. These wastes can cause problems for the environment as well as humans [1]. According to the Food and Agriculture Organization (FAO), Iran is the largest producer of pistachios in the world, and in recent years, the total pistachio by-products in Iran have increased by nearly 310 thousand tons and have caused many environmental problems [2]. Pistachio peel is one of the by-products of pistachio processing. Pistachio peel is classified as agricultural waste, and the discharge of these substances into the environment causes the release of annoying odors and the growth and reproduction of flies. Moreover, most farmers bury pistachio peel in pistachio orchards. Since pistachio peel contains unstable organic matter, it damages the roots of the plant and stops its growth [3]. Many pistachio byproducts are best used as animal feed. However, pistachio waste has a high level of polyphenolic compounds and phenolic compounds that cause the adhesion of proteins, carbohydrates, and minerals in the digestive tract of living organisms, the high consumption of these compounds is highly toxic [4]. . .