Background: Inflammation is one of the main causes of obesity and type 2 diabetes due to obesity and can increase metabolic disorders. Because exercise and diet are effective in reducing inflammation, Hence, Present Study Examined the Effects Of 24 Weeks Interventions On IL-6 Index Changes in Obesity Type 2 Diabetic Men: Influenced by HIIT And Diet Regimes Methods: In this study, 70 men (Obese Type 2 Diabetic Patients) were randomly assigned into 7 groups (4 groups in different diet plus HIIT intervention and 3 groups only in different diet) that involved adherence to a 1, 200 kcal/day for 1 week until 1, 900 kcal/d diet for 24 weeks while participating in a supervised HIIT (12 week) followed with 4 weeks primarily diet regimes. Diet regimes consist of standard diet (50% CHO, 32% fat), low carbohydrate diet (25% CHO, 57% fat; 70% of 57% fat was unsaturated fat), low fat diet (67% CHO, 15% fat) and high fat (25% CHO, 57% fat; 50% of 57% fat was saturates fat), while protein was 18% for all groups. Anthropometrics and physiologies parameters, Body composition and fasting blood samples were obtained at 0, 4, 8, 14, 20 and 24 weeks. Data were analyzed by repeated measures analysis, one-way ANOVA test. Data are presented as mean± SD changes from baseline. Results: results indicated that between differences times wasn’ t show significant different (F (5, 315) =3. 66; P=0. 002; η 2=0. 055). also results demonstrated that within groups changes interactions don’ t show significant different (F (5, 315) =1. 61; P=0. 025; η 2=0. 133). This results also revelated that maximum increase and decrease of IL-6 was in high fat diet (28. 09± 19. 80) and low CHO+HIIT (-28. 89± 25. 13) after 24 weeks interventions. maximum increase and decrease of IL-6 was in high fat diet (26. 74± 25. 33) and low fat +HIIT (-32. 11± 29. 17) After 12 weeks HIIT + diet interventions. Conclusion: Results support contentions that different diet regimes and exercise were selectively aﬀ ects Pro Inflammatory markers and that changes in low CHO and low fat plus HIIT and low CHO meals plus with HIIE may be benefit for obese type 2 diabetic patients.