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Information Journal Paper

Title

EFFECT OF L-CARNITINE SUPPLEMENT ON SEMEN PARAMETERS IN MEN WITH IDIOPATHIC INFERTILITY

Pages

  19-23

Abstract

 Background: It is proposed that L-CARNITINE is a useful agent for treatment of various dysfunctions of sperm in infertile MEN. So, in the present study, effect of L-CARNITINE supplement on SPERM PARAMETERS in MEN with IDIOPATHIC INFERTILITY was evaluated.Materials and methods: Thirty infertile MEN, aged between 20 and 40 years, with the following baseline sperm selection criteria, including sperm count< 66.6×106, motility< 30%, viability< 60%, normal morphology< 35%, were studied. Patients received 3 gram per day L-CARNITINE for six months. Semen analysis was performed according to World Health Organization guidelines before study, and 3 and 6 months of therapy. SPERM PARAMETERS included liquefaction, pH, volume, sperm count, motility, viability and normal morphology.Results: The results showed that L-CARNITINE supplementation increased significantly sperm count, motility, viability and normal morphogy and pregnancy rate after 3 months (p<0.01) and 6 months (p<0.001). Also, L-CARNITINE supplementation increased sperm motility and viability in idiophatic infertile MEN after 3 and 6 months (p<0.001). Five couples became pregnant during the study.Conclusion: The present study indicated that L-CARNITINE supplementation is an appropriate drug in the treatment of MEN with IDIOPATHIC INFERTILITY.

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