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Information Journal Paper

Title

Antioxidant and anti-inflammatory activities of methanol and aqueous extracts of Sargassum wightii

Pages

  75-82

Abstract

 Introduction: Antioxidants of natural sources for the treatment of many ailments have taken priority since the last decades. Recently, researches have been focused on marine algae as they are the largest reservoir of bioactive compounds. Hence, the objective of this study was to explore the in-vitro antioxidant and anti-inflammatory activities of methanolic and aqueous extracts of Sargassum wightii. Methods: The total phenolics, flavonoids, and ascorbic acid (AA) contents were evaluated in forms of gallic acid equivalent (GAE), rutin equivalent (RUE), and AA equivalent, respectively. The aqueous and methanolic extracts were isolated. The antioxidant activities were explored using 2, 2-diphenyl-1-picrylhydrazil (DPPH), superoxide dismutase (SOD), hydroxyl radical scavenging, and ferric reducing power assays. The in vitro anti-inflammatory activity was assayed using nitric oxide radical scavenging, inhibition of Protein denaturation, and antiproteinase activities. Results: We observed significant changes in DPPH scavenging activity with both methanolic Sargassum extract (MSE) and aqueous Sargassum extract (ASE) [IC50: 511. 15 μ g/mL and 927. 05 μ g/mL, respectively]. Methanolic extract showed a greater SOD scavenging activity [IC50: 369. 56 μ g/mL] and hydroxyl radical scavenging potential [IC50: 668. 93 μ g/mL] than that of ASE [SOD, IC50: 923. 94 μ g/mL; hydroxyl ion, IC50: 953. 57 μ g/mL]. In the Ferric reducing antioxidant power assay, MSE and ASE exhibited absorbance of 0. 93 ± 0. 12 and 0. 59 ± 0. 08, respectively, at 1200 μ g/mL each. Both methanol and ASEs showed NO– scavenging activity having IC50 in order, AA (96. 46 μ g/mL)

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    APA: Copy

    Rout, Sradhasini, Rath, Bandana, BHATTAMISRA, SUBRAT KUMAR, Rath, Ishani, & Kumar, Anjan. (2022). Antioxidant and anti-inflammatory activities of methanol and aqueous extracts of Sargassum wightii. JOURNAL OF HERBMED PHARMACOLOGY, 11(1), 75-82. SID. https://sid.ir/paper/975964/en

    Vancouver: Copy

    Rout Sradhasini, Rath Bandana, BHATTAMISRA SUBRAT KUMAR, Rath Ishani, Kumar Anjan. Antioxidant and anti-inflammatory activities of methanol and aqueous extracts of Sargassum wightii. JOURNAL OF HERBMED PHARMACOLOGY[Internet]. 2022;11(1):75-82. Available from: https://sid.ir/paper/975964/en

    IEEE: Copy

    Sradhasini Rout, Bandana Rath, SUBRAT KUMAR BHATTAMISRA, Ishani Rath, and Anjan Kumar, “Antioxidant and anti-inflammatory activities of methanol and aqueous extracts of Sargassum wightii,” JOURNAL OF HERBMED PHARMACOLOGY, vol. 11, no. 1, pp. 75–82, 2022, [Online]. Available: https://sid.ir/paper/975964/en

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