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Information Journal Paper

Title

COMPARATIVE EVALUATION OF GARLIC AND ATORVASTATIN EFFECTS ON LIPID PROFILES CHANGES IN DOG

Pages

 Start Page 93 | End Page 102

Abstract

 The purpose of the present study was to evaluate the effects of GARLIC and ATORVASTATIN on lipid profile changes in DOGs and the influence of time on treatment process. For this purpose, 15 male DOGs, 1- 2 years old were randomly divided into 3 groups with 5 animals in each group. Group A (control) included five DOGs were fed with CHOLESTEROL powder (4 g/kg for 10 days) to induce hyperlipidemia. Group B was similar to group A, but in addition CHOLESTEROL, ATORVASTATIN (5 mg/kg) was administered for 45 days. Group C was similar to group B, with the difference that GARLIC (100 mg/kg body) was administered instead of ATORVASTATIN. Blood samples were collected four times during zero, 10, 40 and 55 days after start of study. Serum total CHOLESTEROL, TRIGLYCERIDEs, HDL-C and LDL-C were measured by using commercial kits.ATORVASTATIN (p<0.001) and GARLIC (p<0.01) showed an effective hypolipidemic activity in reducing blood TRIGLYCERIDE. In comparison between two drugs and their effects on TRIGLYCERIDE, ATORVASTATIN showed a significant difference with GARLIC (p<0.01). Concerning the effects of drugs on CHOLESTEROL level, a significant lowering was seen in the group receiving ATORVASTATIN than GARLIC on day 40 (p<0.05). The treated groups (B and C), had good results in reduction of LDL-C, on day 55 (p<0.001). In comparison between two drug and their effects on HDL-C, a significant difference was seen between groups A and B, on day 55 (p<0.01).The present study showed that both ATORVASTATIN and GARLIC have hypolipidemic activity in DOGs, but ATORVASTATIN was more effective than GARLIC.

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