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Information Seminar Paper

Title

PLASMA SESTRIN 2 IS SIGNIFICANTLY REDUCED IN OBESE CHILDREN AND IS ASSOCIATED WITH LOWERED HDL-C LEVELS

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Abstract

 BACKGROUND AND AIM: THE PREVALENCE OF CHILDHOOD OBESITY HAS INCREASED WORLDWIDE IN RECENT DECADES. THERE IS AMPLE EVIDENCE SUGGESTING THAT CHILDHOOD OBESITY LEADS TO ADULT OBESITY. CHILDHOOD OBESITY, WHICH IS ASSOCIATED WITH METABOLIC DISTURBANCES, USUALLY LEADS TO INSULIN RESISTANCE (IR), HYPERTENSION, GLUCOSE INTOLERANCE, AND TYPE 2 DIABETES MELLITUS. SESTRINS ARE A FAMILY OF STRESS-INDUCIBLE PROTEINS THAT REGULATE METABOLIC HOMEOSTASIS AND INCLUDE THREE MEMBERS (SESTRIN 1-3) IN MAMMALS. ...

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