Seminar Paper

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Information Seminar Paper

Title

SEPARATION AND DETERMINATION OF AMITRIPTYLINE AND IMIPRAMINE BY AIR- ASSISTED LIQUID-LIQUID MICRO-EXTRACTION COMBINED WITH GAS CHROMATOGRAPHY FLAME IONIZATION DETECTION

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 Start Page | End Page

Keywords

GAS CHROMATOGRAPHY (GC) 
FLAME IONIZATION DETECTOR (FID) 

Abstract

 BACKGROUND: TREATMENT OF DEPRESSION INCLUDES VARIOUS FORMS OF PSYCHOTHERAPY AS WELL AS PHARMACOTHERAPY WITH MEDICINES. THE TRICYCLIC ANTIDEPRESSANTS (TCAS), ONE OF THE LARGEST GROUPS OF DRUGS FOR TREATMENT OF PSYCHIATRIC DISORDERS, ARE WIDELY USED FOR TREATMENT OF DEPRESSION [1]. THE MEASUREMENT OF CONCENTRATION OF THESE DRUGS IN BIOLOGICAL FLUIDS IS BECOMING INCREASINGLY IMPORTANT AS AN AID FOR EFFECTIVE CONTROL OF THERAPY AND FORENSIC MEDICAL EXAMINATIONS. FOR THIS GROUP OF DRUGS, DISTINCT RANGES OF OPTIMUM PLASMA CONCENTRATION FOR THERAPY ARE REQUIRED (100–300 G L−1 FOR MOST OF THETCAS) [2]...

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