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Title

THE PREVALENCE OF ANTIBIOTICS RESISTANCE IN ESCHERICHIA COLI AND KLEBSIELLA STRAINS ISOLATED FROM HOSPITALIZED PATIENTS OF TALEGHANI HOSPITAL IN TEHRAN, IRAN

Pages

 Start Page | End Page

Keywords

MULTIDRUG-RESISTANT (MDR) 

Abstract

 BACKGROUND AND AIM: THE MOST IMPORTANT BACTERIA THAT CAUSE THE URINARY TRACT INFECTION ARE ESCHERICHIA COLI AND KLEBSIELLA, THIS BACTERIA CAN ACQUIRE ANTIBIOTIC RESISTANCES BECAUSE OF BETALACTAMASES. THE AIM OF THIS STUDY WAS INVESTIGATING THE PREVALENCE OF ANTIBIOTICS RESISTANCE IN E.COLI AND KLEBSIELLA STRAINS ISOLATED FROM HOSPITALIZED PATIENTS OF TALEGHANI HOSPITAL IN TEHRAN IN 2014.METHODS: THIS STUDY WAS CROSS-SECTIONAL. SPECIMENS WERE COLLECTED FROM TALEGHANI HOSPITAL IN TEHRAN, IRAN. THE ORGANISMS WERE IDENTIFIED BY BIOCHEMICAL TESTS. EVALUATION OF ANTIBIOTIC RESISTANCE WAS PERFORMED BY DISC DIFFUSION METHOD ACCORDING TO CLSI GUIDELINES.RESULTS: 65 SPECIMENS WERE ISOLATED, 27 OUT OF 43 SAMPLES OF E.COLI AND 12 OUT OF 22 SAMPLES OF KLEBSIELLA WERE MULTIDRUG-RESISTANCE (MDR). DRUG SENSITIVITIES PATTERN OF E.COLI SHOWED THAT AMIKACIN WAS ACTIVE AGAINST (%85) OF ISOLATES FOLLOWED BY TRIMETHOPRIM-SULFAMETOXAZOLE (24%), GENTAMICIN (62%), CEFTAZIDIME (58%), CIPROFLOXACIN (48%), CEFOTAXIME (40%), NITROFURANTOIN (80%). ANTIBIOTIC SUSCEPTIBILITY TESTING IN KLEBSIELLA SHOWED THAT GENTAMICIN (78%), CEFTAZIDIME (55%), CIPROFLOXACIN (57%), CEFOTAXIME (47%), AMIKACIN (56%)….

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