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Title

PREVALENCE OF BLA CTX-M GENE AMONG CLINICAL ISOLATES OFK.PENUMONIAE IN CENTRAL PARTS OFIRAN

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Abstract

 BACKGROUND AND AIM: ESBL-PRODUCING K. PNEUMONIA ARE INCREASINGLY BEEN REPORTED AS THE CAUSE OF SEVERE INFECTIONS IN INTENSIVE CARE AND SURGICAL UNITS. A CROSS SECTIONAL STUDY WAS CARRIED OUT TO INVESTIGATE THE PREVALENCE OF THE CTX-M EXTENDED- SPECTRUM B -LACTAMASE GENES IN KLEBSIELLA PNEUMONIA ISOLATED FROM CLINICAL SAMPLE IN, ARAK-IRAN.METHODS: A TOTAL OF 100 K. PNEUMONIA ISOLATES WERE COLLECTED FROM CLINICAL SPECIMENS OBTAINEDIN THE VALIASR HOSPITAL BETWEEN MARCH AND SEPTEMBER’S 2011. THE ANTIMICROBIAL SUSCEPTIBILITY PATTERN WAS DETERMINED BY USING THE STANDARD DISK DIFFUSION METHOD ACCORDING TO CLSI GUIDELINES. THE DISTRIBUTION OF CTX-M-1, CTX-M-2, CTX-M-8 AND CTX-M-9 GENES IN ALL ISOLATES WERE DETERMINED BY POLYMERASE CHAIN REACTION METHOD….

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