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Title

NANOCURCUMIN EFFECT ON DRUG RESISTANT STRAINS OFPSEUDOMONAS AERUGINOSA

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Abstract

 BACKGROUND AND AIM: PSEUDOMONAS AERUGINOSA IS A GRAM-NEGATIVE OPPORTUNISTIC PATHOGEN AND IS A COMMON CAUSE OF NOSOCOMIAL INFECTIONS. CURCUMIN AS AN HERBAL DRUG HAS ANTI-INFLAMMATORY AND ANTI-CANCER PROPERTIES. AIM OF THE STUDY WAS TO INVESTIGATE THE ANTI-BACTERIAL POTENTIAL OF CURCUMIN AGAINST 11 CLINICAL ISOLATES OF PSEUDOMONAS AERUGINOSA IN COMBINATION WITH CIPROFLOXACIN.METHODS: HEREIN, WE ISOLATED 50 CLINICAL STRAINS OF PSEUDOMONAS AERUGINOSA FROM PATIENTS IN GUILAN PROVINCE. AFTER MIC DETERMINATION, 11 CIPROFLOXACIN (CP) RESISTANT ISOLATES WERE TREATED BY CIPROFLOXACIN ONLY AND IN THE COMBINATION WITH NANO-CURCUMIN (NANO-PARTICLE ENCAPSULATED CURCUMIN). ANTIMICROBIAL ACTIVITY OF NANO-CURCUMIN WAS ASSESSED BY CALCULATING THE MIC AND OD600 AFTER 24H AND 48H….

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