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Title

SYNTHESIS OF FUNCTIONALIZED MESOPOROUS SILICA NANOPARTICLE AS NANO-CARRIER IN DRUG DELIVERY SYSTEM: EXPERIMENTAL DESIGN TO OPTIMIZE THE DRUG LOADING PROCESS

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Abstract

 BACKGROUND: CURCUMIN, DIACETHYLCURCUMIN AND BIS-DEMETHOXY CURCUMIN, ARE THE ACTIVE CURCUMINOIDS OF TURMERIC WITH MANY PHYSIOLOGICAL, BIOCHEMICAL, AND PHARMACOLOGICAL PROPERTIES. HOWEVER, APPLICATION OF THIS COMPOUND AS AN ANTI-CANCER DRUG IS LIMITED BECAUSE OF ITS LOW LEVEL OF UPTAKE AND TISSUE DISTRIBUTION, LOW ACTIVITY, RAPID METABOLISM AND PRODUCTS' INACTIVITY. TO OVERCOME THIS PROBLEM, NANOCARRIERS CAN BE USED TO MAKE DRUG DELIVERS EFFICIENTLY AND ROBUSTLY [1]...

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