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Information Seminar Paper

Title

DNA BINDING STUDIES OF CLODINAFOP-PROPARGYL

Pages

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Abstract

 PESTICIDES HAVE BEEN EXTENSIVELY APPLIED IN RECENT DECADES IN AGRICULTUREL THROUGHOUT THE WORLD. THEY ARE POWERFUL TOXICANTS WHICH ARE EASILY ABSORBED AND TEND TO ACCUMULATE ONTO THE SOIL, PLANTS, FOODS, GROUND AND SURFACE WATERS. THE IN VITRO GENOTOXICITY STUDY OF ORGANOCHLORO HERBICIDES IS VERY LACK. SO THE OBJECTIVE OF THE PRESENT STUDY WAS TO EVALUATE THE GENOTOXIC EFFECTS OF THE CLODINAFOP-PROPARGYL (CP), WHICH IS WIDELY USED IN PEST-CONTROL PROGRAMS IN AGRICULTURE AND IN PUBLIC HEALTH AS WELL.CP CLASSIFIED AS "LIKELY TO BE CARCINOGENIC TO HUMANS" BY THE ORAL ROUTE BASED ON THE OCCURRENCE OF PROSTATE TUMORS IN MALE RATS, OVARIAN TUMORS IN FEMALE RATS, AND LIVER TUMORS IN BOTH SEXES OF MICE, AS WELL AS BLOOD VESSEL TUMORS IN FEMALE MICE.1 THIS COMPOUND IS HYDROLYZED WITHIN PLANT TISSUES TO RELEASE THE PHYTOTOXIC ACID OR ALCOHOL.2 IT ALSO TARGETS THE FATTY ACID BIOSYNTHETIC PATHWAY OF GRASSES BY INHIBITING THE PLASTID FORM OF THE ENZYME ACETYL- COA CARBOXYLASE (ACCASE; EC 6.4.1.2).

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