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Information Seminar Paper

Title

UN-STRUCTURED KINETIC MODELS FOR RH-GCSF PRODUCTION BY ESCHERICHIA COLI IN A FED BATCH REACTOR BEFORE AND AFTER INDUCTION

Pages

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Abstract

 TWO UN-STRUCTURED KINETIC MODEL FOR RH-GCSF PRODUCTION BYESCHERICHIA COLI IN A FED BATCH REACTOR ARE PROPOSED. ONE OF THEM PREDICTS PRODUCTION OF RH-GCSF BEFORE INDUCTION WHEN CONCENTRATION OF GLUCOSE DECREASES. THE OTHER ONE PREDICTS PRODUCTION OF RH-GCSF AFTER INDUCTION. WE CALCULATE PARAMETERS OF THE KINETIC MODELS BY FITTING MODELS TO EXPERIMENTAL DATA. THESE EXPERIMENTAL DATA HAVE BEEN OBTAINED IN EXPERIMENTS IN A FED BATCH REACTOR. SUGGESTED MODELS ARE UNSTRUCTURED NONSEGREGATED. R2 OF THE MODEL THAT PREDICTS PRODUCTION BEFORE INDUCTION IS EQUAL TO 0.9356 AND AFTER INDUCTION IS ABOUT 0.9966.

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