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Information Seminar Paper

Title

SARA: SURFACE AREA ANALYSIS TOOL

Pages

 Start Page | End Page

Abstract

 AGGREGATION IS KNOWN AS A MAJOR PROBLEM DURING PROTEIN BIOSYNTHESIS AND EXPERIMENTAL WORK. AGGREGATION OR INCLUSION BODY FORMATION IS A SIDE-REACTION OF PROTEIN FOLDING WHICH ALWAYS HAPPENS DUE TO INTERMOLECULAR INTERACTION BETWEEN HYDROPHOBIC PATCHES. HAVING A TOOL FOR ANALYSIS OF THE HYDROPHOBIC PATCHES CHANGES CAN HELP US TO REDUCE THE DIFFICULTIES OF THIS TYPE. WE INTRODUCE A DEVELOPED VERSION OF ASA ANALYSIS PROGRAM WHICH CALCULATES THE ACCESSIBLE SURFACE AREA (ASA) FOR A PDB FILE PER EACH GROUP OF AMINO ACIDS AND THEREFORE WE CAN HAVE A PLOT OF HYDROPHOBICITY OF POLYPEPTIDE WHICH SHOWS THE BEHAVIOR OF THE POLYPEPTIDE. THIS METHOD CAN HELP US TO DETERMINE THE MANNER OF THE PROTEINS WHICH AND ASSESSMENT OF AGGREGATION.

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