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Information Seminar Paper

Title

INHIBITION OF NITRIC OXIDE SYNTHASE BY L-NAME PROMOTES CISPLATIN-INDUCED NEPHROTOXICITY: GENDER RELATED DIFFERENCE

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Abstract

 OBJECTIVE: NITRIC OXIDE (NO) HAS NUMEROUS IMPORTANT FUNCTIONS IN THE KIDNEY. NO CONCENTRATION IN SERUM IS ALTERED BY CISPLATIN (CP), AND NO INFLUENCES CP-INDUCED NEPHROTOXICITY, HOWEVER, THE ROLE OF NO IN CP-INDUCED NEPHROTOXICITY IS STILL UNCLEAR. THE AIM OF THE PRESENT STUDY WAS TO DETERMINE THE ROLE OF NO SYNTHASE INHIBITOR (L-NAME) ON THE SEVERITY OF CP-INDUCED NEPHROTOXICITY IN MALE AND FEMALE RATS. …

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