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Title

EVALUATION OF EFFICACY OF CHOLERA TOXIN (CT) AS AN ADJUVANT IN THE ENHANCEMENT OF IMMUNE RESPONSES AGAINST UROPATHOGENIC ESCHERICHIA COLI ANTIGENS

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Abstract

 BACKGROUND AND AIM: URINARY TRACT INFECTIONS (UTIS) CAUSED BY UROPATHOGENIC ESCHERICHIA COLI (UPEC) ARE AMONG THE MOST COMMON INFECTIONS IN HUMAN. ANTIBIOTICS ARE COMMON THERAPY FOR UTIS, BUT INCREASE IN ANTIBIOTIC RESISTANCE WILL COMPLICATE FUTURE TREATMENT OF THE INFECTIONS, MAKING THE DEVELOPMENT OF AN EFFICACIOUS UTI VACCINE MORE URGENT. IN THIS STUDY, WE ASSESSED INTRANASALLY THE ADJUVANT PROPERTIES OF CHOLERA TOXIN (CT) OF VIBRIO CHOLERA IN DIFFERENT VACCINE PREPARATIONS WITH FIMH AND FLIC ANTIGENS OF UPEC STRAINS....

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