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Title

STUDY ON BM86 SIMILAR STRUCTURE IN IRANIAN TICK SPECIES BY DEVELOPMENT OF INDIRECT ELISA USING BM86 SPECIFIC MAB

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Abstract

 BACKGROUND AND AIM: CONCEALED VERSUS EXPOSED ANTIGEN WAS USED AS MAIN PRINCIPLE TO DEVELOP VACCINE AGAINST TICK SPECIES. BM86 IS A SPECIFIC GLYCOPROTEIN WHICH IS PRIMARILY FOUND IN MIDGUT EPITHELIAL CELLS OF PARTICULAR TICK SPECIES; DUE TO ITS CRUCIAL ROLE IN MID-GUT EPITHELIAL CELL AND ITS CONCEALED FEATURE, THIS GLYCOPROTEIN WAS USED FOR MAKING OF VACCINE (TICK GARD AND GAVAC IN AUSTRALIA AND CUBA, RESPECTIVELY) AGAINST BOOPHILUSMICROPLUS TICK SPECIES. SINCE IRAN'S PREDOMINANT TICKS SPECIES ARE COMPLETELY DIFFERENT FROM ABOVE MENTIONED TICK, IN THIS STUDY WE ATTEMPTED TO DEVELOP INDIRECT ELISA TEST TO FIND OUT SIMILAR BM86 STRUCTURE IN IRANIAN TICK SPECIES USING OUR DEVELOPED BM86 SPECIFIC MAB...

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