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Title

P274- PRECONDITIONING WITH OXIDATIVE STRESS INCREASES THE SURVIVAL RATE IN BONE MARROW-DERIVED MESENCHYMAL STEM CELLS

Pages

 Start Page | End Page

Abstract

 INTRODUCTION: MESENCHYMAL STEM CELLS ARE MULTIPOTENT STEM CELLS HAVING CAPACITY FOR DIFFERENTIATION TO VARIOUS TYPES OF CELLS SUCH AS OSTEOCYTE, ADIPOCYTE, AND CHONDROCYTES. THEY CAN BE EASILY ISOLATED FROM SEVERAL ORGANS WITHOUT ANY PROMINENT INVASIVE PROCEDURE. BOTH DIFFERENTIATION ABILITY AND IMMUNOMODULATORY EFFECTS OF THE BONE MARROW–DERIVED MESENCHYMAL STEM CELLS (BM-MSCS) MAKE THEM TO BE A PROMISING SOURCE FOR TISSUE REPAIRING AND VEHICLES OF CELL-BASED GENE THERAPY. MOREOVER, THE HOMING PROPERTIES OF BM-MSCS OFFER THEM TO BE A PROSPECTIVE TOOL FOR AUGMENTING OF THE TISSUE REGENERATION. NEVERTHELESS, SOME DISADVANTAGES INCLUDING LOW SURVIVAL RATE FOLLOWING TRANSPLANTATION WILL BE RESULTED BY A LOT OF OXIDATIVE STRESS CAUSED BY HYPOXIA/INFLAMMATION IN DAMAGED TISSUE. THESE CONDITIONS RESTRICT THE BROAD APPLICATIONS OF BM-MSCS FOR CLINICAL PURPOSES. THEREFORE, EACH STRATEGY PROTECTING BM-MSCS FROM PREMATURE DEATH AND IMPROVING THE SURVIVAL RATE WILL BE VALUABLE FOR THEIR THERAPEUTIC AIMS. PRECONDITIONING DENOTES THE CELL EXPOSURE TO MINUTE RATE OF OXIDATIVE STRESS FOR A SHORT PERIOD OF TIME, REINFORCING THE CELLS AGAINST THE HIGHER LEVEL OF STRESS...

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