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Title

P273- USING NANOPARTICLES FOR LABELING AND TRACKING STEM CELLS IN MEDICINE

Pages

 Start Page | End Page

Keywords

CONJUGATED POLYMER BASED WATER- DISPERSIBLE NANOPARTICLES (CPN) 

Abstract

 INTRODUCTION: STEM CELLS ARE ONE OF THE MOST FASCINATING AREAS OF BIOLOGY TODAY. THEY HAVE THE REMARKABLE POTENTIAL TO DEVELOP INTO MANY DIFFERENT CELL TYPES IN THE BODY. OVER THE PAST DECADE THE USE OF STEM CELLS HAS OPENED UP A NEW FRONTIER IN CLINICAL TREATMENT. WITH SO MANY STEM CELL REPLACEMENT THERAPIES GOING THROUGH CLINICAL TRIALS CURRENTLY, THERE IS A GREAT NEED TO UNDERSTAND THE MECHANISMS BEHIND A SUCCESSFUL THERAPY, AND ONE OF THE CRITICAL POINTS OF DISCOVERING THEM IS TO TRACK STEM CELL MIGRATION, PROLIFERATION AND DIFFERENTIATION IN VIVO. TO BE OF MOST USE TRACKING METHODS SHOULD IDEALLY BE NON-INVASIVE, HIGH RESOLUTION AND ALLOW TRACKING IN THREE DIMENSIONS. MAGNETIC RESONANCE IMAGING (MRI) IS ONE OF THE IDEAL METHODS, BUT REQUIRES A SUITABLE CONTRAST AGENT TO BE LOADED TO THE CELLS TO BE TRACKED, AND ONE OF THE MOST WIDE-SPREAD IN STEM CELL TRACKING IS A GROUP OF AGENTS KNOWN AS NANOPARTICLES. NANOPARTICLES (NPS) ARE PARTICLES BETWEEN 1 AND 100 NANOMETERS IN SIZE. GOLD AND SILICA NANOPARTICLES ARE KNOWN AS ONE OF THE MOST IMPORTANT GROUP OF NANOPARTICLES USE FOR STEM SELL TRACKING IN MEDICINE. THE AIM OF THIS REVIEW ARTICLE IS TO INTRODUCE THE WAYS BY WHICH NANOPARTICLES WERE USED FOR LABELING AND TRACKING STEM CELLS...

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