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Title

P252- SUSPENSION CULTIVATION OF WHARTON’S JELLY-DERIVED MESENCHYMAL STEM CELLS IMPROVES THEIR SUPPORTIVE EFFECTS ON HEMATOPOIETIC STEM CELLS

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Abstract

 OBJECTIVE: WHARTON’S JELLY, AN APPROPRIATE SOURCE OF MESENCHYMAL STEM CELLS (MSCS), HAS BEEN SHOWN TO HAVE PARACRINE ABILITY TO SUPPORT HEMATOPOIETIC STEM CELLS (HSCS) PROLIFERATION AND EXPANSION IN VITRO. HOWEVER, THE WJ-DERIVED MSCS ARE VERY HETEROGENEOUS AND HAVE LIMITED CAPACITY TO SECRET OR PRODUCE IMPORTANT CYTOKINES THAT INVOLVE IN HEMATOPOIESIS. HENCE, IMPROVEMENT OF THEIR CULTURE CONDITION WOULD PROMOTE THE EFFICIENCY OF WJ-MSCS. THIS STUDY CONDUCTED TO EMPLOY A SIMPLE CULTURING METHOD FOR WJ-MSCS WHICH PROMOTES THEIR HEMATOPOIETIC CYTOKINES...

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