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Title

P250- RECOVERY OF BEHAVIORAL SYMPTOMS IN HEMI-PARKINSONIAN RATS AFTER INTRAVENOUS INJECTION OF ADIPOSE DERIVED STEM CELLS- CONDITIONED MEDIUM

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Abstract

 OBJECTIVE: PARKINSON'S DISEASE (PD), A PROGRESSIVE NEURODEGENERATIVE DISORDER, IS CHARACTERIZED BY LOSS OF DOPAMINERGIC NEURONS OF THE NIGROSTRIATAL PATHWAY WHICH CAUSED MOTOR DISABILITY. ADIPOSE DERIVED STEM CELLS (ASCS) CAN BE REGARDED AS AN EXCELLENT CANDIDATE FOR CELL THERAPY DUE TO ITS EASY ACCESSIBILITY, EXPANSION, AND FREE OF ETHICAL CONCERNS. VARIOUS STUDIES ON STEM CELL-DERIVED SECRETED FACTORS SHOWED THAT THE SECRETED FACTOR ALONE WITHOUT THE STEM CELL ITSELF MAY CAUSE TISSUE REPAIR IN VARIOUS CONDITIONS THAT INVOLVED TISSUE/ORGAN DAMAGE. IN THIS RESEARCH, WE CARRIED OUT INTRAVENOUS ADMINISTRATION OF ASCS-CONDITIONED MEDIUM ON PD MODEL OF RATS AND EVALUATED ITS THERAPEUTIC EFFECTS FOCUSING ON MOTOR IMPROVEMENT...

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