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Title

P235- THE ROLES OF NON-CODING RNAS IN MATURATION OF HUMAN EMBRYONIC STEM CELL CARDIOMYOCYTES

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Abstract

 INTRODUCTION: WHAT IS THE NECESSITY UPON DIFFERENTIATING HUMAN EMBRYONIC STEM CELL CARDIOMYOCYTES (HESC-CMS)? AN ABSOLUTE REASON IS SIGNIFICANT DIFFERENCES EXIST BETWEEN HUMAN AND COMMON EXPERIMENTAL ANIMALS, INCLUDING SIZE, HEART RATE, ION CHANNEL CONTRIBUTIONS, DISTINCT DEVELOPMENTAL PROCESSES, ANOTHER HURDLE IS THAT DISEASES CAN NOT BE MODELED WELL IN ANIMALS, AS WELL AS LACK OF SUFFICIENT AND HEALTHY HUMAN CARDIAC TISSUES FOR EXPERIMENTAL RESEARCH, SO HESC-CMS HAVE COME IN TO VIEW AS AN ATTRACTIVE MODEL...

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